Original ContributionsExtraskeletal myxoid chondrosarcoma: A clinicopathologic, immunohistochemical, and molecular analysis of 18 cases☆,☆☆
Section snippets
Materials
Eighteen cases of EMCS were selected from the files of soft tissue tumors of the authors (H.H., T. Ishida, T. Imamura, and H.K.), and the original hematoxylin and eosin–stained slides of each case were reviewed. In 1 of the 18 cases, the clinicopathologic, ultrastructural, and cytogenetic findings had been reported previously (case 5).25 Initially, 21 cases were originally diagnosed as EMCS, but 3 of them were excluded from the present study because they were reclassified as other tumor
Clinical findings
Clinical details of the 18 patients are summarized in Table 3.There were 10 men and 8 women, whose ages ranged from 26 to 75 years (median, 45 years; mean, 47.4 years). The tumors were located in the thigh (8 cases), upper arm (2 cases), lower leg (2 cases), buttock (1 case), shoulder (1 case), back (1 case), foot (1 case), finger (1 case), and hip joint (1 case). The duration of a symptom before diagnosis ranged from 2 months to 25 years (median, 4 years; mean, 5.1 years). All patients
Discussion
EMCSs account for approximately 2.5% of soft tissue sarcoma,9 commonly occur in middle-aged adults, and arise mainly in the proximal extremities and limb girdles. Generally, EMCS is considered a tumor showing chondroid differentiation. Chondroid differentiation has been suggested by the results of histochemical or immunohistochemical studies showing the presence of chondroitin-4 and 6-sulphate in an intercellular matrix in EMCS9, 11, 13 and S-100 protein positivity,3, 13 by the ultrastructural
Acknowledgements
The authors thank the following pathologists for providing case material and clinical information to this study: Dr S. Teshima, Douai Memorial Hospital; Dr K. Mizuguchi, Mizonokuchi Hospital, Teikyo University School of Medicine; Dr T. Kasuga, Nakano General Hospital; Drs H. Horiuchi and S. Matsuya, Kanto Medical Center NTT EC; Dr K. Hara, Aichi Medical University; Dr K. Iwasaki, Sasebo Municipal General Hospital; Dr M. Takeshita, National Hospital Kyushu Medical, Center; Dr S. Era, Beppu
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Supported in part by grants-in-aid from the Ministry of Education, Science, Sports and Culture, Japan (12770102 and 12670184), and by a grant from the Fukuoka Cancer Society, Japan, 2000.
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Address correspondence and reprint requests to Hiroshi Hashimoto, MD, Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.