ORIGINAL ARTICLEMusashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity
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RNA-binding proteins in cancer drug discovery
2023, Drug Discovery TodayTNF-α up-regulates Nanog by activating NF-κB pathway to induce primary rat spinal cord astrocytes dedifferentiation
2021, Life SciencesCitation Excerpt :Variant CD44 epitopes can also be found in astrocytic tumors [38]. In addition, Musashi-1 is an evolutionally conserved marker for central nervous system progenitor cells and glioma cells [39,40]. Musashi-1 is an RNA-binding protein that appears to function in the proliferation of stem cells [41].
Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer
2019, Pharmacology and TherapeuticsCitation Excerpt :The Musashi proteins have also been linked to cancer (Fox et al., 2015; Kudinov, Karanicolas, Golemis, & Boumber, 2017). For example, elevated expression of MSI1 was found in gliomas (Kanemura et al., 2001) and medulloblastomas (Vo, Subramaniam, et al., 2012). In line with this, MSI1 overexpression correlates with poor prognosis in breast cancer patients (Wang et al., 2010) and promotes the metastasis of breast cancer cells to lungs (Oskarsson et al., 2011).
Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation
2019, Journal of Biological ChemistryCitation Excerpt :Recent evidence suggests that Musashi may also play a role in controlling plasticity of more differentiated cells (11, 12). Consistent with the physiological control of stem cell maintenance, Musashi1 and Musashi2 have also been implicated pathologically in the promotion of cancer stem cell self-renewal and disease progression (13–24). The Musashi proteins were originally identified as repressors of target mRNA translation (1, 8, 25, 26).