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UVA, UVB and incidence of cutaneous malignant melanoma in Norway and Sweden

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Abstract

Latitudinal dependencies of UVA and UVB were studied together with relevant epidemiological data for squamous cell carcinoma (SCC) and cutaneous malignant melanoma (CMM) in Norway and Sweden. Our data support the hypothesis that solar UVA radiation may play a role for CMM induction. The etiologies of SCC and CMM are different according to a latitudinal dependency and differences in age curves. Sun exposure patterns, age-related decay rates of repair of UV damage and sex hormones may play different roles for the two skin cancers. Also, UVB induction of vitamin D may be involved. CMM incidence rates among young people have decreased or been constant since about 1990 in Norway and Sweden. All reasons for UVA contributing to CMM will be discussed.

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References

  1. U. Leiter, C. Garbe, Epidemiology of melanoma and nonmelanoma skin cancer–the role of sunlight, Adv. Exp. Med. Biol., 2008, 624, 89–103.

    PubMed  Google Scholar 

  2. R. M. Mackie, Long-term health risk to the skin of ultraviolet radiation, Prog. Biophys. Mol. Biol., 2006, 92, 92–96.

    PubMed  Google Scholar 

  3. P. Boukamp, UV-induced skin cancer: similarities–variations, J. Dtsch. Dermatol. Ges., 2005, 3, 493–503.

    PubMed  Google Scholar 

  4. K. Y. Tsai, H. Tsao, The genetics of skin cancer, Am. J. Med. Genet., 2004, 131C, 82–92.

    PubMed  Google Scholar 

  5. F. R. de Gruijl, H. J. Sterenborg, P. D. Forbes, R. E. Davies, C. Cole, G. Kelfkens, H. van Weelden, H. Slaper, J. C. van der Leun, Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice, Cancer Res., 1993, 53, 53–60.

    PubMed  Google Scholar 

  6. International Organization for Standardization (ISO), International Commission on Illumination (CIE): International Standard ISO 17166:1999(E)-CIE 007/E:1998, Erythema Reference Action Spectrum and Standard Erythema Dose, International Organization for Standardization (ISO), Geneva, Switzerland, 1999.

    Google Scholar 

  7. R. B. Setlow, E. Grist, K. Thompson, A. D. Woodhead, Wavelengths effective in induction of malignant melanoma, Proc. Natl. Acad. Sci. U. S. A., 1993, 90, 6666–6670.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. T. M. Runger, Role of UVA in the pathogenesis of melanoma and non-melanoma skin cancer. A short review, Photodermatol., Photoimmunol. Photomed., 1999, 15, 212–216.

    CAS  PubMed  Google Scholar 

  9. S. Q. Wang, R. Setlow, M. Berwick, D. Polsky, A. A. Marghoob, A. W. Kopf, R. S. Bart, Ultraviolet A and melanoma: a review, J. Am. Acad. Dermatol., 2001, 44, 837–846.

    CAS  PubMed  Google Scholar 

  10. L. P. Lund, G. S. Timmins, Melanoma, long wavelength ultraviolet and sunscreens: controversies and potential resolutions, Pharmacol. Ther., 2007, 114, 198–207.

    CAS  PubMed  Google Scholar 

  11. J. Moan, A. C. Porojnicu, A. Dahlback, Ultraviolet radiation and malignant melanoma, Adv. Exp. Med. Biol., 2008, 624, 104–116.

    PubMed  Google Scholar 

  12. K. Rass, J. Reichrath, UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer, Adv. Exp. Med. Biol., 2008, 624, 162–178.

    CAS  PubMed  Google Scholar 

  13. D. S. Rigel, Epidemiology of melanoma, Semin. Cutaneous Med. Surg., 2010, 29, 204–209.

    CAS  Google Scholar 

  14. M. S. Tang, Ultraviolet a light: potential underlying causes of melanoma, Future Oncol., 2010, 6, 1523–1526.

    CAS  PubMed  Google Scholar 

  15. O. Hallberg, O. Johansson, Malignant melanoma of the skin - not a sunshine story!, Med. Sci. Monit., 2004, 10, CR336–CR340.

    PubMed  Google Scholar 

  16. S. Gandini, F. Sera, M. S. Cattaruzza, P. Pasquini, O. Picconi, P. Boyle, C. F. Melchi, Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure, Eur. J. Cancer, 2005, 41, 45–60.

    PubMed  Google Scholar 

  17. E. L. Rager, E. P. Bridgeford, D. W. Ollila, Cutaneous melanoma: update on prevention, screening, diagnosis, and treatment, Am. Fam. Physician, 2005, 72, 269–276.

    PubMed  Google Scholar 

  18. S. A. Oliveria, M. Saraiya, A. C. Geller, M. K. Heneghan, C. Jorgensen, Sun exposure and risk of melanoma, Arch. Dis. Child., 2005, 91, 131–138.

    PubMed  PubMed Central  Google Scholar 

  19. Y. M. Chang, J. H. Barrett, D. T. Bishop et al., Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls, Int. J. Epidemiol., 2009, 38, 814–830.

    PubMed  PubMed Central  Google Scholar 

  20. E. Erdei, S. M. Torres, A new understanding in the epidemiology of melanoma, Expert Rev. Anti-Infect. Ther., 2010, 10, 1811–1823.

    Google Scholar 

  21. R. D. Ley, Animal models of ultraviolet radiation (UVR)-induced cutaneous melanoma, Front. Biosci., 2002, 7, d1531–d1534.

    PubMed  Google Scholar 

  22. G. Kroumpouzos, M. M. Konstadoulakis, H. Cabral, C. P. Karakousis, Risk of basal cell and squamous cell carcinoma in persons with prior cutaneous melanoma, Dermatol. Surg., 2000, 26, 547–550.

    CAS  PubMed  Google Scholar 

  23. I. K. Crombie, Variation of melanoma incidence with latitude in North America and Europe, Br. J. Cancer, 1979, 40, 774–781.

    CAS  PubMed  PubMed Central  Google Scholar 

  24. J. Moan, A. Dahlback, R. B. Setlow, Epidemiological support for an hypothesis for melanoma induction indicating a role for UVA radiation, Photochem. Photobiol., 1999, 70, 243–247.

    CAS  PubMed  Google Scholar 

  25. N. K. Hayward, Mutation spectrum of the first melanoma genome points finger firmly at ultraviolet light as the primary carcinogen, Pigm. Cell Melanoma Res., 2010, 23, 153–154.

    CAS  Google Scholar 

  26. H. Ikehata, T. Ono, The Mechanisms of UV Mutagenesis, J. Radiat. Res., 2011, 52, 115–125.

    CAS  PubMed  Google Scholar 

  27. M. Situm, Z. Bolanca, M. Buljan, Lentigo maligna melanoma–the review, Coll. Antropol., 2010, 34(Suppl 2) 299–301.

    PubMed  Google Scholar 

  28. R. Hofmann-Wellenhof, H. P. Soyer, I. H. Wolf, J. Smolle, S. Reischle, E. Rieger, R. O. Kenet, P. Wolf, H. Kerl, Ultraviolet radiation of melanocytic nevi: a dermoscopic study, Arch. Dermatol., 1998, 134, 845–850.

    CAS  PubMed  Google Scholar 

  29. S. Gandini, F. Sera, M. S. Cattaruzza, P. Pasquini, R. Zanetti, C. Masini, P. Boyle, C. F. Melchi, Meta-analysis of risk factors for cutaneous melanoma: III. Family history, actinic damage and phenotypic factors, Eur. J. Cancer, 2005, 41, 2040–2059.

    PubMed  Google Scholar 

  30. C. M. Olsen, H. J. Carroll, D. C. Whiteman, Estimating the attributable fraction for melanoma: a meta-analysis of pigmentary characteristics and freckling, Int. J. Cancer, 2010, 127, 2430–2445.

    CAS  PubMed  Google Scholar 

  31. N. Maddodi, V. Setaluri, Role of UV in cutaneous melanoma, Photochem. Photobiol., 2008, 84, 528–536.

    CAS  PubMed  Google Scholar 

  32. K. Byrd-Miles, E. L. Toombs, G. L. Peck, Skin cancer in individuals of African, Asian, Latin-American, and American-Indian descent: differences in incidence, clinical presentation, and survival compared to Caucasians, J. Drugs Dermatol., 2007, 6, 10–16.

    PubMed  Google Scholar 

  33. P. Autier, J. F. Dore, O. Gefeller, J. P. Cesarini, F. Lejeune, K. F. Koelmel, D. Lienard, U. R. Kleeberg, Melanoma risk and residence in sunny areas. EORTC Melanoma Co-operative Group. European Organization for Research and Treatment of Cancer, Br. J. Cancer, 1997, 76, 1521–1524.

    CAS  PubMed  PubMed Central  Google Scholar 

  34. A. L. Kadekaro, K. Wakamatsu, S. Ito, Z. A. Abdel-Malek, Cutaneous photoprotection and melanoma susceptibility: reaching beyond melanin content to the frontiers of DNA repair, Front. Biosci., 2006, 11, 2157–2173.

    CAS  PubMed  Google Scholar 

  35. A. Sarasin, P. Dessen, DNA repair pathways and human metastatic malignant melanoma, Curr. Mol. Med., 2010, 10, 413–418.

    CAS  PubMed  Google Scholar 

  36. G. M. Kraehn, M. Schartl, R. U. Peter, Human malignant melanoma. A genetic disease?, Cancer, 1995, 75, 1228–1237.

    CAS  PubMed  Google Scholar 

  37. J. Di Lucca, M. Guedj, V. Descamps, A. Bourillon, P. Dieude, P. Saiag, P. Wolkenstein, N. Dupin, C. Lebbe, N. Basset-Seguin, B. Grandchamp, N. Soufir, Interactions between ultraviolet light exposure and DNA repair gene polymorphisms may increase melanoma risk, Br. J. Dermatol., 2009, 162, 891–893.

    Google Scholar 

  38. K. H. Kraemer, Xeroderma Pigmentosum, University of Washington, Seattle, Seattle (WA), 1993.

    Google Scholar 

  39. International Agency for Research on Cancer Working Group on artificial ultraviolet (UV) light and skin cancer, The association of use of sunbeds with cutaneous malignant melanoma and other skin cancers: A systematic review, Int. J. Cancer, 2007, 120, 1116–1122.

    Google Scholar 

  40. W. Ting, K. Schultz, N. N. Cac, M. Peterson, H. W. Walling, Tanning bed exposure increases the risk of malignant melanoma, Int. J. Dermatol., 2007, 46, 1253–1257.

    PubMed  Google Scholar 

  41. D. Lazovich, R. I. Vogel, M. Berwick, M. A. Weinstock, K. E. Anderson, E. M. Warshaw, Indoor tanning and risk of melanoma: a case-control study in a highly exposed population, Cancer Epidemiol., Biomarkers Prev., 2010, 19, 1557–1568.

    PubMed  Google Scholar 

  42. M. B. Veierod, H. O. Adami, E. Lund, B. K. Armstrong, E. Weiderpass, Sun and solarium exposure and melanoma risk: effects of age, pigmentary characteristics, and nevi, Cancer Epidemiol., Biomarkers Prev., 2010, 19, 111–120.

    PubMed  Google Scholar 

  43. K. R. Cooke, D. C. Skegg, J. Fraser, Socio-economic status, indoor and outdoor work, and malignant melanoma, Int. J. Cancer, 1984, 34, 57–62.

    CAS  PubMed  Google Scholar 

  44. F. C. Garland, M. R. White, C. F. Garland, E. Shaw, E. D. Gorham, Occupational sunlight exposure and melanoma in the U.S. Navy, Arch. Environ. Health, 1990, 45, 261–267.

    CAS  PubMed  Google Scholar 

  45. E. Pukkala, J. I. Martinsen, E. Lynge, H. K. Gunnarsdottir, P. Sparen, L. Tryggvadottir, E. Weiderpass, K. Kjaerheim, Occupation and cancer - follow-up of 15 million people in five Nordic countries, Acta Oncol., 2009, 48, 646–790.

    CAS  PubMed  Google Scholar 

  46. A. Yakubu, O. A. Mabogunje, Skin cancer in African albinos, Acta Oncol., 1993, 32, 621–622.

    CAS  PubMed  Google Scholar 

  47. J. Moan, A. C. Porojnicu, A. Dahlback, R. B. Setlow, Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure, Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 668–673.

    CAS  PubMed  PubMed Central  Google Scholar 

  48. M. Berwick, B. K. Armstrong, L. Ben-Porat, J. Fine, A. Kricker, C. Eberle, R. Barnhill, Sun exposure and mortality from melanoma, J. Natl. Cancer Inst., 2005, 97, 195–199.

    PubMed  Google Scholar 

  49. R. T. Vollmer, Solar elastosis in cutaneous melanoma, Am. J. Clin. Pathol., 2007, 128, 260–264.

    PubMed  Google Scholar 

  50. E. Giovannucci, The epidemiology of vitamin D and cancer incidence and mortality: a review (United States), Cancer, Causes Control, 2005, 16, 83–95.

    PubMed  Google Scholar 

  51. S. Field, J. A. Newton-Bishop, Melanoma and vitamin D, Mol. Oncol., 2011, 5, 197–214.

    CAS  PubMed  PubMed Central  Google Scholar 

  52. D. E. Godar, R. J. Landry, A. D. Lucas, Increased UVA exposures and decreased cutaneous Vitamin D(3) levels may be responsible for the increasing incidence of melanoma, Med. Hypotheses, 2009, 72, 434–443.

    CAS  PubMed  Google Scholar 

  53. C. Fortes, E. de Vries, Nonsolar occupational risk factors for cutaneous melanoma, Int. J. Dermatol., 2008, 47, 319–328.

    PubMed  Google Scholar 

  54. J. Cadet, T. Douki, Oxidatively generated damage to DNA by UVA radiation in cells and human skin, J. Invest. Dermatol., 2011, 131, 1005–1007.

    CAS  PubMed  Google Scholar 

  55. L. T. Nilsen, T. N. Aalerud, M. Hannevik, M. B. Veierod, UVB and UVA irradiances from indoor tanning devices, Photochem. Photobiol. Sci., 2011, 10, 1129–1136.

    CAS  PubMed  Google Scholar 

  56. B. Gerber, P. Mathys, M. Moser, D. Bressoud, C. Braun-Fahrlander, Ultraviolet emission spectra of sunbeds, Photochem. Photobiol., 2002, 76, 664–668.

    CAS  PubMed  Google Scholar 

  57. B. L. Diffey, Sunscreens as a preventative measure in melanoma: an evidence-based approach or the precautionary principle?, Br. J. Dermatol., 2009, 161(Suppl 3) 25–27.

    PubMed  Google Scholar 

  58. B. Diffey, Sunscreens: expectation and realization, Photodermatol., Photoimmunol. Photomed., 2009, 25, 233–236.

    PubMed  Google Scholar 

  59. E. D. Gorham, S. B. Mohr, C. F. Garland, G. Chaplin, F. C. Garland, Do sunscreens increase risk of melanoma in populations residing at higher latitudes?, Ann. Epidemiol., 2007, 17, 956–963.

    PubMed  Google Scholar 

  60. R. Neale, G. Williams, A. Green, Application patterns among participants randomized to daily sunscreen use in a skin cancer prevention trial, Arch. Dermatol., 2002, 138, 1319–1325.

    PubMed  Google Scholar 

  61. L. H. Kligman, R. M. Sayre, An action spectrum for ultraviolet induced elastosis in hairless mice: quantification of elastosis by image analysis, Photochem. Photobiol., 1991, 53, 237–242.

    CAS  PubMed  Google Scholar 

  62. R. D. Ley, Ultraviolet radiation A-induced precursors of cutaneous melanoma in Monodelphis domestica, Cancer Res., 1997, 57, 3682–3684.

    CAS  PubMed  Google Scholar 

  63. E. C. De Fabo, F. P. Noonan, T. Fears, G. Merlino, Ultraviolet B but not ultraviolet A radiation initiates melanoma, Cancer Res., 2004, 64, 6372–6376.

    PubMed  Google Scholar 

  64. E. C. De Fabo, Initial studies on an in vivo action spectrum for melanoma induction, Prog. Biophys. Mol. Biol., 2006, 92, 97–104.

    PubMed  Google Scholar 

  65. R. D. Ley, Dose response for ultraviolet radiation A-induced focal melanocytic hyperplasia and nonmelanoma skin tumors in Monodelphis domestica, Photochem. Photobiol., 2001, 73, 20–23.

    CAS  PubMed  Google Scholar 

  66. D. L. Mitchell, A. A. Fernandez, R. S. Nairn, R. Garcia, L. Paniker, D. Trono, H. D. Thames, I. Gimenez-Conti, Ultraviolet A does not induce melanomas in a Xiphophorus hybrid fish model, Proc. Natl. Acad. Sci. U. S. A., 2010, 107, 9329–9334.

    CAS  PubMed  PubMed Central  Google Scholar 

  67. C. Garbe, U. Leiter, Melanoma epidemiology and trends, Clin. Dermatol., 2009, 27, 3–9.

    PubMed  Google Scholar 

  68. M. P. Staples, M. Elwood, R. C. Burton, J. L. Williams, R. Marks, G. G. Giles, Non-melanoma skin cancer in Australia: the 2002 national survey and trends since 1985, Med J. Aust., 2006, 184, 6–10.

    PubMed  Google Scholar 

  69. P. H. Youl, M. Janda, J. F. Aitken, C. B. Del Mar, D. C. Whiteman, P. D. Baade, Body-site distribution of skin cancer, pre-malignant and common benign pigmented lesions excised in general practice, Br. J. Dermatol., 2011, 165, 35–43.

    CAS  PubMed  Google Scholar 

  70. J. Moan, A. Dahlback, Z. Lagunova, E. Cicarma, A. C. Porojnicu, Solar radiation, vitamin D and cancer incidence and mortality in Norway, Anticancer Res., 2009, 29, 3501–3509.

    CAS  PubMed  Google Scholar 

  71. J. M. Elwood, R. P. Gallagher, Body site distribution of cutaneous malignant melanoma in relationship to patterns of sun exposure, Int. J. Cancer, 1998, 78, 276–280.

    CAS  PubMed  Google Scholar 

  72. J. L. Bulliard, D. De Weck, T. Fisch, A. Bordoni, F. Levi, Detailed site distribution of melanoma and sunlight exposure: aetiological patterns from a Swiss series, Ann. Oncol., 2006, 18, 789–794.

    Google Scholar 

  73. E. de Vries, F. I. Bray, J. W. Coebergh, D. M. Parkin, Changing epidemiology of malignant cutaneous melanoma in Europe 1953-1997: rising trends in incidence and mortality but recent stabilizations in western Europe and decreases in Scandinavia, Int. J. Cancer, 2003, 107, 119–126.

    PubMed  Google Scholar 

  74. A. Jemal, S. S. Devesa, P. Hartge, M. A. Tucker, Recent trends in cutaneous melanoma incidence among whites in the United States, J. Natl. Cancer Inst., 2001, 93, 678–683.

    CAS  PubMed  Google Scholar 

  75. D. C. Whiteman, C. A. Bray, V. Siskind, A. C. Green, D. J. Hole, R. M. Mackie, Changes in the incidence of cutaneous melanoma in the west of Scotland and Queensland, Australia: hope for health promotion?, Eur. J. Cancer Prev., 2008, 17, 243–250.

    PubMed  Google Scholar 

  76. P. M. Karlsson, M. Fredrikson, Cutaneous malignant melanoma in children and adolescents in Sweden,1993–2002: the increasing trend is broken, Int. J. Cancer, 2007, 121, 323–328.

    CAS  PubMed  Google Scholar 

  77. D. K. Pruthi, R. Guilfoyle, Z. Nugent, M. C. Wiseman, A. A. Demers, Incidence and anatomic presentation of cutaneous malignant melanoma in central Canada during a 50-year period: 1956 to 2005, J. Am. Acad. Dermatol., 2009, 61, 44–50.

    PubMed  Google Scholar 

  78. J. Moan, Z. Lagunova, E. Cicarma, L. Aksnes, A. Dahlback, W. B. Grant, A. C. Porojnicu, Sunbeds as vitamin D sources, Photochem. Photobiol., 2009, 85, 1474–1479.

    CAS  PubMed  Google Scholar 

  79. A. Dahlback, J. Moan, Annual exposures to carcinogenic radiation from the sun at different latitudes and amplification factors related to ozone depletion. The use of different geometrical representations of the skin surface receiving the ultraviolet radiation, Photochem. Photobiol., 1990, 52, 1025–1028.

    CAS  PubMed  Google Scholar 

  80. A. C. Porojnicu, Z. Lagunova, T. E. Robsahm, J. P. Berg, A. Dahlback, J. Moan, Changes in risk of death from breast cancer with season and latitude: sun exposure and breast cancer survival in Norway, Breast Cancer Res. Treat., 2006, 102, 323–328.

    PubMed  Google Scholar 

  81. J. Moan, A. Porojnicu, Z. Lagunova, J. P. Berg, A. Dahlback, Colon cancer: prognosis for different latitudes, age groups and seasons in Norway, J. Photochem. Photobiol., B, 2007, 89, 148–155.

    CAS  PubMed  Google Scholar 

  82. R. Vieth, How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology, Anticancer Res., 2009, 29, 3675–3684.

    CAS  PubMed  Google Scholar 

  83. K. M. Egan, Vitamin D and melanoma, Ann. Epidemiol., 2009, 19, 455–461.

    PubMed  Google Scholar 

  84. J. A. Newton-Bishop, Y. M. Chang, F. Elliott, M. Chan, S. Leake, B. Karpavicius, S. Haynes, E. Fitzgibbon, K. Kukalizch, J. Randerson-Moor, D. E. Elder, D. T. Bishop, J. H. Barrett, Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate, Eur. J. Cancer, 2011, 47, 732–741.

    PubMed  PubMed Central  Google Scholar 

  85. E. Cicarma, A. Juzeniene, A. C. Porojnicu, O. S. Bruland, J. Moan Latitude, gradient for melanoma incidence by anatomic site and gender in Norway 1966–2007, J. Photochem. Photobiol., B, 2010, 101, 174–178.

    CAS  PubMed  Google Scholar 

  86. A. E. Cust, B. K. Armstrong, C. Goumas, M. A. Jenkins, H. Schmid, J. L. Hopper, R. F. Kefford, G. G. Giles, J. F. Aitken, G. J. Mann, Sunbed use during adolescence and early adulthood is associated with increased risk of early-onset melanoma, Int. J. Cancer, 2011, 128, 2425–2435.

    CAS  PubMed  PubMed Central  Google Scholar 

  87. P. Autier, J. F. Dore, A. M. Eggermont, J. W. Coebergh, Epidemiological evidence that UVA radiation is involved in the genesis of cutaneous melanoma, Curr. Opin. Oncol., 2011, 23, 189–196.

    PubMed  Google Scholar 

  88. S. G. Coelho, V. J. Hearing, UVA tanning is involved in the increased incidence of skin cancers in fair-skinned young women, Pigm. Cell Melanoma Res., 2010, 23, 57–63.

    Google Scholar 

  89. F. Elliott, M. Suppa, M. Chan, S. Leake, B. Karpavicius, S. Haynes, J. H. Barrett, D. T. Bishop, J. A. Newton-Bishop, Relationship between sunbed use and melanoma risk in a large case-control study in the United Kingdom, Int. J. Cancer, 2011 10.1002/ijc.26347.

    Google Scholar 

  90. J. Moan, E. Cicarma, R. Setlow, A. C. Porojnicu, W. B. Grant, A. Juzeniene, Time trends and latitude dependence of uveal and cutaneous malignant melanoma induced by solar radiation, Derm.-Endocrinol., 2010, 2, 3–8.

    Google Scholar 

  91. J. Moan, A. C. Porojnicu, A. Dahlback, W. B. Grant, A. Juzeniene, Where the sun does not shine: is sunshine protective against melanoma of the vulva?, J. Photochem. Photobiol., B, 2010, 101, 179–183.

    CAS  PubMed  Google Scholar 

  92. K. Magnus, The Nordic profile of skin cancer incidence. A comparative epidemiological study of the three main types of skin cancer, Int. J. Cancer, 1991, 47, 12–19.

    CAS  PubMed  Google Scholar 

  93. C. Greenman, P. Stephens, R. Smith et al., Patterns of somatic mutation in human cancer genomes, Nature, 2007, 446, 153–158.

    CAS  PubMed  PubMed Central  Google Scholar 

  94. E. D. Pleasance, R. K. Cheetham, P. J. Stephens et al., A comprehensive catalogue of somatic mutations from a human cancer genome, Nature, 2009, 463, 191–196.

    PubMed  PubMed Central  Google Scholar 

  95. L. Sadoff, J. Winkley, S. Tyson, Is malignant melanoma an endocrine-dependent tumor? The possible adverse effect of estrogen, Oncology, 1973, 27, 244–257.

    CAS  PubMed  Google Scholar 

  96. E. R. Koomen, A. Joosse, R. M. Herings, M. K. Casparie, H. J. Guchelaar, T. Nijsten, Estrogens, oral contraceptives and hormonal replacement therapy increase the incidence of cutaneous melanoma: a population-based case-control study, Ann. Oncol., 2008, 20, 358–364.

    PubMed  Google Scholar 

  97. M. Kvaskoff, A. Bijon, S. Mesrine, M. C. Boutron-Ruault, F. Clavel-Chapelon, Cutaneous Melanoma and Endogenous Hormonal Factors: A Large French Prospective Study, Am. J. Epidemiol., 2011, 173, 1192–1202.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Biology, Institute for Cancer Research, the Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310, Oslo, Norway

    Johan Moan, Zivile Baturaite, Alina Carmen Porojnicu & Asta Juzeniene

  2. Institute of Physics, University of Oslo, Blindern, 0316, Oslo, Norway

    Johan Moan & Arne Dahlback

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  1. Johan Moan
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  2. Zivile Baturaite
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  3. Alina Carmen Porojnicu
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  5. Asta Juzeniene
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Correspondence to Asta Juzeniene.

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This article is dedicated to the memory of Dr Egil Kvam for his important work in photobiology and for his contributions to our scientific communities through scientific discussions and through friendship. Egil Kvam pioneered investigations on the relationship between UVA and skin cancer

Contribution to the themed issue on the biology of UVA

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Moan, J., Baturaite, Z., Porojnicu, A.C. et al. UVA, UVB and incidence of cutaneous malignant melanoma in Norway and Sweden. Photochem Photobiol Sci 11, 191–198 (2012). https://doi.org/10.1039/c1pp05215b

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