Issue 11, 2011
From the journal:

Natural Product Reports

The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)

Daniel Krahn,a   Christian Ottmannb  and  Markus Kaiser*a  

* Corresponding authors

a Zentrum für Medizinische Biotechnologie, Fakultät Biologie, Universität Duisburg-Essen, Universitätsstr. 2, Essen, Germany
E-mail: markus.kaiser@uni-due.de

b Chemical Genomics Centre der Max-Planck-Gesellschaft, Otto-Hahn-Str. 15, Dortmund, Germany

Abstract

Covering: up to March 2011

Syrbactin is a subordinate term for the syringolin, glidobactin and cepafungin natural product families. Their grouping is based on their related molecular frameworks, similar biosynthesis pathways and, most importantly, identical modes-of-action, being irreversible proteasome inhibition. With this report, we aim to review their chemical biology, describing their common, but also differential characteristics.

Graphical abstract: The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)

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Article information

DOI
https://doi.org/10.1039/C1NP00048A
Article type
Review Article
Submitted
08 Jun 2011
First published
09 Sep 2011

Nat. Prod. Rep., 2011,28, 1854-1867

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The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)

D. Krahn, C. Ottmann and M. Kaiser, Nat. Prod. Rep., 2011, 28, 1854 DOI: 10.1039/C1NP00048A

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