Abstract
Skeletal morbidity secondary to metastases and osteoporosis is common in patients with advanced prostate cancer. Despite the typically sclerotic nature of prostate cancer metastases, osteoclast mediated osteolysis may play a significant role. This review addresses the newly recognised antitumour effects of bisphosphonates in addition to their role in inhibiting osteoclast mediated bone resorption. Both preclinical and clinical evidence of a role for bisphosphonates in the treatment and prevention of bone metastases secondary to prostate cancer is assessed.
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Oades, G., Coxon, J. & Colston, K. The potential role of bisphosphonates in prostate cancer. Prostate Cancer Prostatic Dis 5, 264–272 (2002). https://doi.org/10.1038/sj.pcan.4500607
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DOI: https://doi.org/10.1038/sj.pcan.4500607
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