Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

The Id proteins and angiogenesis

Abstract

Since the identification of the Id proteins over a decade ago, a great many cell cycle and cell fate decisions have been shown to be under the control of these proteins as described in other sections of this review issue. Perhaps the most unsuspected activity of this class of proteins has been their essential role in angiogenesis, both in the forebrain during development and during the growth and metastasis of tumors in adults. This section of the review issue will focus on the key observations which have led to these conclusions, speculations about potential mechanisms and the outlook for potential therapeutic interventions.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  • Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM . 1997 Science 275: 964–967

  • Bader BL, Rayburn H, Crowley D, Hynes RO . 1998 Cell 95: 507–519

  • Barleon B, Sozzani S, Zhou D, Weich HA, Mantovani A, Marme D . 1996 Blood 87: 3336–3343

  • Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H . 1990 Cell 61: 49–59

  • Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E . 1999 J. Clin. Invest. 103: 159–165

  • Benjamin LE, Keshet E . 1997 Proc. Natl. Acad. Sci. USA 94: 8761–8766

  • Bergers G, Javaherian K, Lo KM, Folkman J, Hanahan D . 1999 Science 284: 808–812

  • Breier G, Risau W . 1996 Trends Cell Biol. 6: 454–456

  • Brogi E, Schatteman G, Wu T, Kim EA, Varticovski L, Keyt B, Isner JM . 1996 J. Clin. Invest. 97: 469–476

  • Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA . 1994 Cell 79: 1157–1164

  • Caprioli A, Jaffredo T, Gautier R, Dubourg C, Dieterlen-Lievre F . 1998 Proc. Natl. Acad. Sci. USA 95: 1641–1646

  • Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A . 1996 Nature 380: 435–439

  • Chen B, Lim RW . 1997 J. Biol. Chem. 272: 2459–2463

  • Christy BA, Sanders LK, Lau LF, Copeland NG, Jenkins NA, Nathans D . 1991 Proc. Natl. Acad. Sci. USA 88: 1815–1819

  • Clauss M, Weich H, Breier G, Knies U, Rockl W, Waltenberger J, Risau W . 1996 J. Biol. Chem. 271: 17629–17634

  • Coffin JD, Harrison J, Schwartz S, Heimark R . 1991 Dev. Biol. 148: 51–62

  • Coussens LM, Tinkle CL, Hanahan D, Werb Z . 2000 Cell 103: 481–490

  • Crews ST . 1998 Genes Dev. 12: 607–620

  • Desprez PY, Lin CQ, Thomasset N, Sympson CJ, Bissell MJ, Campisi J . 1998 Mol. Cell. Biol. 18: 4577–4588

  • Duncan M, DiCicco-Bloom EM, Xiang X, Benezra R, Chada K . 1992 Dev. Biol. 154: 1–10

  • Ellmeier W, Weith A . 1995 Dev. Dyn. 203: 163–173

  • Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell-Braxton L, Hillan KJ, Moore MW . 1996 Nature 380: 439–442

  • Flamme I, Breier G, Risau W . 1995 Dev. Biol. 169: 699–712

  • Folkman J . 1995 Nat. Med. 1: 27–31

  • Folkman J, Shing Y . 1992 J. Biol. Chem. 267: 10931–10934

  • Fong GH, Rossant J, Gertsenstein M, Breitman ML . 1995 Nature 376: 66–70

  • Gill M, Dias S, Hattori K, Rivera ML, Hicklin D, Witte L, Girardi L, Yurt R, Himel H, Rafii S . 2001 Circ. Res. 88: 167–174

  • Hanahan D . 1997 Science 277: 48–50

  • Hanahan D, Folkman J . 1996 Cell 86: 353–364

  • Hattori K, Dias S, Heissig B, Hackett NR, Lyden D, Tateno M, Hicklin DJ, Zhu Z, Witte L, Crystal RG, Moore MA, Rafii S . 2001 J. Exp. Med. 193: 1005–1014

  • Holash J, Maisonpierre D, Compton D, Boland P, Alexander CR, Zagzag D, Yancopoulos GD, Wiegland SJ . 1999 Science 284: 1994–1998

  • Iavarone A, Garg P, Lasorella A, Hsu J, Israel MA . 1994 Genes Dev. 8: 1270–1284

  • Jen Y, Manova K, Benezra R . 1997 Dev. Dyn. 208: 92–106

  • Jen Y, Weintraub H, Benezra R . 1992 Genes Dev. 6: 1466–1479

  • Kageyama R, Sasai Y, Akazawa C, Ishibashi M, Takebayashi K, Shimizu C, Tomita K, Nakanishi S . 1995 Crit. Rev. Neurobiol. 9: 177–188

  • Langlands K, Yin X, Anand G, Prochownik EV . 1997 J. Biol. Chem. 272: 19785–19793

  • Lassar AB, Skapek SX, Novitch B . 1994 Curr. Opin. Cell. Biol. 6: 788–794

  • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N . 1989 Science 246: 1306–1309

  • Lin Y, Weisdorf DJ, Solovey A, Hebbel RP . 2000 J. Clin. Invest. 105: 71–77

  • Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, Chadburn A, Heyssig B, Marks W, Hackett RN, Crystal CR, Moore ASM, Hajjur AK, Manova K, Rafii S, Benezra R . 2001 Nat. Med. 11: 1194–1201

  • Lyden D, Young AZ, Zagzag D, Yan W, Gerald W, O'Reilly R, Bader BL, Hynes RO, Zhuang Y, Manova K, Benezra R . 1999 Nature 401: 670–677

  • Matthews W, Jordan CT, Gavin M, Jenkins NA, Copeland NG, Lemischka IR . 1991 Proc. Natl. Acad. Sci. USA 88: 9026–9030

  • Mitola S, Sozzani S, Luini W, Primo L, Borsatti A, Weich H, Bussolino F . 1997 Blood 90: 1365–1372

  • Neuhold LA, Wold B . 1993 Cell 74: 1033–1042

  • Neuman T, Keen A, Zuber MX, Kristjansson GI, Gruss P, Nornes HO . 1993 Dev. Biol. 160: 186–195

  • Norton JD, Deed RW, Craggs G, Sablitzky F . 1998 Trends Cell. Biol. 8: 58–65

  • Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, Sharrocks AD, Peters G, Hara E . 2001 Nature 409: 1067–1070

  • Ortega N, Jonca F, Vincent S, Favard C, Ruchoux MM, Plouet J . 1997 Am. J. Pathol. 151: 1215–1224

  • Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, Oz MC, Hicklin DJ, Witte L, Moore MA, Rafii S . 2000 Blood 95: 952–958

  • Pepper MS . 1997 Arterioscler. Thromb. Vasc. Biol. 17: 605–619

  • Perlman JM, Volpe JJ . 1986 Am. J. Dis. Child. 140: 1122–1124

  • Pesce S, Benezra R . 1993 Mol. Cell. Biol. 13: 7874–7880

  • Plate KH, Breier G, Weich HA, Risau W . 1992 Nature 359: 845–848

  • Quertermous EE, Hidai H, Blanar MA, Quertermous T . 1994 Proc. Natl. Acad. Sci. USA 91: 7066–7070

  • Rafii S, Oz MC, Seldomridge JA, Ferris B, Asch AS, Nachman RL, Shapiro F, Rose EA, Levin HR . 1995 Ann. Thorac. Surg. 60: 1627–1632

  • Riechmann V, Sablitzky F . 1995 Cell Growth Differ. 6: 837–843

  • Riechmann V, van Cruchten I, Sablitzky F . 1994 Nucl. Acids Res. 22: 749–755

  • Risau W . 1997 Nature 386: 671–674

  • Robert B, St.John PL, Hyink DP, Abrahamson DR . 1996 Am. J. Physiol. 271: F744–F753

  • Roberts EC, Deed RW, Inoue T, Norton JD, Sharrocks AD . 2001 Mol. Cell. Biol. 21: 524–533

  • Ron D, Habener JF . 1992 Genes Dev. 6: 439–453

  • Sato TN, Tozawa Y, Deutsch U, Wolburg-Buchholz K, Fujiwara Y, Gendron-Maguire M, Grid1ey T, Wolburg H, Risau W, Qin Y . 1995 Nature 376: 70–74

  • Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC . 1995 Nature 376: 62–66

  • Shi Q, Rafii S, Wu MH, Wijelath ES, Yu C, Ishida A, Fujita Y, Kothari S, Mohle R, Sauvage LR, Moore MA, Storb RF, Hammond WP . 1998 Blood 92: 362–367

  • Shoji W, Inoue T, Yamamoto T, Obinata M . 1995 J. Biol. Chem. 270: 24818–24825

  • Sigvardsson M, O'Riordan M, Grosschedl R . 1997 Immunity 7: 25–36

  • Spicer DB, Rhee J, Cheung WL, Lassar AB . 1996 Science 272: 1476–1480

  • Sun XH, Copeland NA, Jenkins NA, Baltimore D . 1991 Mol. Cell. Biol. 11: 5603–5611

  • Takahashi T, Kalka C, Masuda H, Chen D, Silver M, Kearney M, Magner M, Isner JM, Asahara T . 1999 Nat. Med. 5: 434–438

  • Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, Bohlen P . 1992 Biochem. Biophys. Res. Commun. 187: 1579–1586

  • Treacy MN, He X, Rosenfeld MG . 1991 Nature 350: 577–584

  • Wang H, Keiser JA . 1998 Circ. Res. 83: 832–840

  • Yan W, Young AZ, Soares VC, Kelley R, Benezra R, Zhuang Y . 1997 Mol. Cell. Biol 17: 7317–7327

  • Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD . 1999 EMBO J. 18: 968–976

  • Zetter BR . 1998 Annu. Rev. Med. 49: 407–424

Download references

Acknowledgements

Dr R Benezra is supported by a grant from the Breast Cancer Research Foundation. Dr S Rafii is supported by the American Cancer Society and The Leukemia and Lymphoma Society. Dr D Lyden is supported by a grant from Doris Duke Charitable Foundation.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert Benezra.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Benezra, R., Rafii, S. & Lyden, D. The Id proteins and angiogenesis. Oncogene 20, 8334–8341 (2001). https://doi.org/10.1038/sj.onc.1205160

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1205160

Keywords

This article is cited by

Search

Quick links