Abstract
Cellular Jun (c-Jun) and viral Jun (v-Jun) can induce oncogenic transformation. For this activity, c-Jun requires an upstream signal, delivered by the Jun N-terminal kinase (JNK). v-Jun does not interact with JNK; it is autonomous and constitutively active. v-Jun and c-Jun address overlapping but not identical sets of genes. Whether all genes essential for transformation reside within the overlap of the v-Jun and c-Jun target spectra remains to be determined. The search for transformation-relevant targets of Jun is moving into a new stage with the application of DNA microarrays technology. Genetic screens and functional tests remain a necessity for the identification of genes that control the oncogenic phenotype.
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References
Abate C, Patel L, Rauscher FJd, Curran T . 1990 Science 249: 1157–1161
Adler V, Franklin CC, Kraft AS . 1992a Proc. Natl. Acad. Sci. USA 89: 5341–5345
Adler V, Fuchs SY, Kim J, Kraft A, King MP, Pelling J, Ronai Z . 1995a Cell Growth Differ. 6: 1437–1446
Adler V. Polotskaya A, Wagner F, Kraft AS . 1992c J. Biol. Chem. 267: 17001–17005
Adler V, Schaffer A, Kim J, Dolan L, Ronai Z . 1995b J. Biol. Chem. 270: 26071–26077
Adler V, Unlap T, Kraft AS . 1994 J. Biol. Chem. 269: 11186–11191
Ainbinder E, Bergelson S, Pinkus R, Daniel V . 1997 Eur. J. Biochem. 243: 49–57
Alani R, Brown P, Binetruy B, Dosaka H, Rosenberg RK, Angel P, Karin M, Birrer MJ . 1991 Mol. Cell. Biol. 11: 6286–6295
Alber T . 1992 Curr. Opin. Genet. Dev. 2: 205–210
Allegretto EA, Smeal T, Angel P, Spiegelman BM, Karin M . 1990 J. Cell. Biochem. 42: 193–206
Angel P, Allegretto EA, Okino ST, Hattori K, Boyle WJ, Hunter T, Karin M . 1988a Nature 332: 166–171
Angel P, Hattori K, Smeal T, Karin M . 1988b Cell 55: 875–885
Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M . 1987 Cell 49: 729–739
Angel P, Smeal T, Meek J, Karin M . 1989 New Biol. 1: 35–43
Antinore MJ, Birrer MJ, Patel D, Nader L, McCance DJ . 1996 EMBO J. 15: 1950–1960
Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M . 1997 Mol. Cell. Biol. 17: 3094–3102
Bader AG, Hartl M, Bister K . 2000 Virology 270: 98–110
Bahr MJ, Vincent KJ, Arthur MJ, Fowler AV, Smart DE, Wright MC, Clark IM, Benyon RC, Iredale JP, Mann DA . 1999 Hepatology 29: 839–848
Baichwal VR, Park A, Tjian R . 1991 Nature 352: 165–168
Baichwal VR, Tjian R . 1990 Cell 63: 815–825
Bakiri L, Lallemand D, Bossy-Wetzel E, Yaniv M . 2000 EMBO J. 19: 2056–2068
Barila D, Mangano R, Gonfloni S, Kretzschmar J, Moro M, Bohmann D, Superti-Furga G . 2000 EMBO J. 19: 273–281
Basso J, Briggs J, Findlay C, Bos T . 2000 Oncogene 19: 4876–4885
Behrens A, Jochum W, Sibilia M, Wagner EF . 2000 Oncogene 19: 2657–2663
Behrens A, Sibilia M, Wagner EF . 1999 Nat. Genet. 21: 326–329
Bengal E, Ransone L, Scharfmann R, Dwarki VJ, Tapscott SJ, Weintraub H, Verma IM . 1992 Cell 68: 507–519
Black EJ, Catling AD, Woodgett JR, Kilbey A, Gillespie DA . 1994 Oncogene 9: 2363–2368
Black EJ, Street AJ, Gillespie DA . 1991 Oncogene 6: 1949–1958
Bohmann D, Bos TJ, Admon A, Nishimura T, Vogt PK, Tjian R . 1987 Science 238: 1386–1392
Bohmann D, Tjian R . 1989 Cell 59: 709–717
Bornberg-Bauer E, Rivals E, Vingron M . 1998 Nucleic Acids. Res. 26: 2740–2746
Bos TJ, Beug H, Graf T, Hayman M, Maki Y, Uckert W, Vogt PK . 1986 Princess Takamatsu Symp. 17: 23–30
Bos TJ, Bohmann D, Tsuchie H, Tjian R, Vogt PK . 1988 Cell 52: 705–712
Bos TJ, Margiotta P, Bush L, Wasilenko W . 1999 Int. J. Cancer 81: 404–410
Bos TJ, Rauscher FJd, Curran T, Vogt PK . 1989 Oncogene 4: 123–126
Bossy-Wetzel E, Bakiri L, Yaniv M . 1997 EMBO J. 16: 1695–1709
Boyle WJ, Smeal T, Defize LH, Angel P, Woodgett JR, Karin M, Hunter T . 1991 Cell 64: 573–584
Bromberg J, Darnell Jr JE . 2000 Oncogene 19: 2468–2473
Brown PH, Alani R, Preis LH, Szabo E, Birrer MJ . 1993 Oncogene 8: 877–886
Brown PH, Kim SH, Wise SC, Sabichi AL, Birrer MJ . 1996 Cell. Growth Differ. 7: 1013–1021
Castellazzi M, Dangy JP, Mechta F, Hirai S, Yaniv M, Samarut J, Lassailly A, Brun G . 1990 Oncogene 5: 1541–1547
Castellazzi M, Spyrou G, La Vista N, Dangy JP, Piu F, Yaniv M, Brun G . 1991 Proc. Natl. Acad. Sci. USA 88: 8890–8894
Cavalieri F, Ruscio T, Tinoco R, Benedict S, Davis C, Vogt PK . 1985 Virology 143: 680–683
Chatton B, Bocco JL, Gaire M, Hauss C, Reimund B, Goetz J, Kedinger C . 1993 Mol. Cell. Biol. 13: 561–570
Cheng J, Yang J, Xia Y, Karin M, Su B . 2000 Mol. Cell. Biol. 20: 2334–2342
Chida K, Nagamori S, Kuroki T . 1999 Cell. Mol. Life Sci. 55: 297–302
Chida K, Vogt PK . 1992 Proc. Natl. Acad. Sci. USA 89: 4290–4294
Claret FX, Hibi M, Dhut S, Toda T, Karin M . 1996 Nature 383: 453–457
Clark W, Gillespie DA . 1997 Cell Growth Differ. 8: 371–380
Cohen DR, Ferreira PC, Gentz R, Franza Jr BR, Curran T . 1989 Genes Dev. 3: 173–184
Cohen SB, Waha A, Gelman IH, Vogt PK . 2001 Oncogene in press
Dai T, Rubie E, Franklin CC, Kraft A, Gillespie DA, Avruch J, Kyriakis JM, Woodgett JR . 1995 Oncogene 10: 849–855
De Graeve F, Bahr A, Sabapathy KT, Hauss C, Wagner EF, Kedinger C, Chatton B . 1999 Oncogene 18: 3491–3500
de Ruiter ND, Wolthuis RM, van Dam H, Burgering BM, Bos JL . 2000 Mol. Cell. Biol. 20: 8480–8488
Dennler S, Prunier C, Ferrand N, Gauthier JM, Atfi A . 2000 J. Biol. Chem. 275: 28858–28865
Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ . 1994 Cell 76: 1025–1037
DeRisi J, Penland L, Brown PO, Bittner ML, Meltzer PS, Ray M, Chen Y, Su YA, Trent JM . 1996 Nat. Genet. 14: 457–460
Diamond MI, Miner JN, Yoshinaga SK, Yamamoto KR . 1990 Science 249: 1266–1272
Domann FE, Levy JP, Birrer MJ, Bowden GT . 1994 Cell Growth Differ. 5: 9–16
Doucas V, Spyrou G, Yaniv M . 1991 EMBO J. 10: 2237–2245
Erlichman J, Gutierrez-Juarez R, Zucker S, Mei X, Orr GA . 1999 Eur. J. Biochem. 263: 797–805
Fialka I, Schwarz H, Reichmann E, Oft M, Busslinger M, Beug H . 1996 J. Cell. Biol. 132: 1115–1132
Frame MC, Wilkie NM, Darling AJ, Chudleigh A, Pintzas A, Lang JC, Gillespie DA . 1991 Oncogene 6: 205–209
Franklin CC, Unlap T, Adler V, Kraft AS . 1993 Cell Growth Differ. 4: 377–385
Fritz G, Kaina B . 1999a Mol. Cell. Biol. 19: 1768–1774
Fritz G, Kaina B . 1999b Oncogene 18: 1033–1040
Fu S, Bottoli I, Goller M, Vogt PK . 1999 Proc. Natl. Acad. Sci. USA 96: 5716–5721
Fu SL, Waha A, Vogt PK . 2000 Oncogene 19: 3537–3545
Gao M, Morgan I, Vogt PK . 1996 Cancer Res. 56: 4229–4235
Garcia M, Samarut J . 1990 J. Virol. 64: 4684–4690
Garcia M, Samarut J . 1993 Proc. Natl. Acad. Sci. USA 90: 8837–8841
Glover JN, Harrison SC . 1995 Nature 373: 257–261
Goller ME, Iacovoni JS, Vogt PK, Kruse U . 1998 Oncogene 16: 2945–2948
Gonzalez MV, Jimenez B, Berciano MT, Gonzalez-Sancho JM, Caelles C, Lafarga M, Munoz A . 2000 J. Cell. Biol. 150: 1199–1208
Gottlicher M, Heck S, Herrlich P . 1998 J. Mol. Med. 76: 480–489
Grossi M, Calconi A, Tato F . 1991 Oncogene 6: 1767–1773
Hadman M, Gabos L, Loo M, Sehgal A, Bos TJ . 1996 Oncogene 12: 135–142
Hadman M, Lin W, Bush L, Bos TJ . 1998 Oncogene 16: 655–660
Hadman M, Loo M, Bos TJ . 1993 Oncogene 8: 1895–1903
Hai T, Curran T . 1991 Proc. Natl. Acad. Sci. USA 88: 3720–3724
Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P . 1988 Cell 55: 917–924
Haluska FG, Huebner K, Isobe M, Nishimura T, Croce CM, Vogt PK . 1988 Proc. Natl. Acad. Sci. USA 85: 2215–2218
Hartkamp J, Troppmair J, Rapp UR . 1999 Cancer Res. 59: 2195–2202
Hartl M, Bister K . 1995 Proc. Natl. Acad. Sci. USA 92: 11731–11735
Hartl M, Bister K . 1998 Oncogene 17: 2901–2913
Hartl M, Hutchins JT, Vogt PK . 1991 Oncogene 6: 1623–1631
Hartl M, Vogt PK . 1992a Cell Growth Differ. 3: 899–908
Hartl M, Vogt PK . 1992b Cell Growth Differ. 3: 909–918
Hartl M, Vogt PK, Bister K . 1995 Virology 207: 321–326
Hattori K, Angel P, Le Beau MM, Karin M . 1998 Proc. Natl. Acad. Sci. USA 85: 9148–9152
Havarstein LS, Morgan IM, Wong WY, Vogt PK . 1992 Proc. Natl. Acad. Sci USA 89: 618–622
Hawker KL, Pintzas A, Hennigan RF, Gillespie DA, Ozanne BW . 1993 J. Virol 67: 5487–5495
Hibi M, Lin A, Smeal T, Minden A, Karin M . 1993 Genes Gev. 7: 2135–2148
Himly M. Foster DN, Bottoli I, Iacovoni JS, Vogt PK . 1998 Virology 248: 295–304
Hirai SI, Ryseck RP, Mechta R, Bravo R, Yaniv M . 1989 EMBO J. 8: 1433–1439
Hirst JD, Vieth M, Skolnick J, Brooks 3rd CL . 1996 Protein Eng. 9: 657–662
Hubank M, Schatz DG . 1999 Methods Enzymol. 303: 325–349
Hughes M, Sehgal A, Hadman M, Bos T . 1992 Cell Growth Differ. 3: 889–897
Huguier S, Baguet J. Perez S, van Dam H, Castellazzi M . 1998 Mol. Cell. Biol. 18: 7020–7029
Hussain S, Kilbey A, Gillespie DA . 1998 Cell Growth Differ. 9: 677–686
Imafuku I, Masaki T, Waragai M, Takeuchi S, Kawabata M, Hirai S, Ohno S, Nee LE, Lippa CF, Kanazawa I, Imagawa M, Okazawa H . 1999 J. Cell. Biol. 147: 121–134
Imler JL, Ugarte E, Wasylyk C, Wasylyk B . 1988 Nucleic Acids. Res. 16: 3005–3012
Ito T, Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H . 2000 J. Biol. Chem. in press
Jurdic P, Treilleux I, Vandel L, Tabone E, Huguier S, Sergeant A, Castellazzi M . 1995 Oncogene 11: 1699–1709
Kallunki T, Deng T, Hibi M, Karin M . 1996 Cell 87: 929–939
Kallunki T, Su B, Tsigelny I, Sluss HK, Derijard B, Moore G, Davis R, Karin M . 1994 Genes Dev. 8: 2996–3007
Kameda T, Akahori A, Sonobe MH, Suzuki T, Endo T, Iba H . 1993 Proc. Natl. Acad. Sci. USA 90: 9369–9373
Kameda T, Iba H . 1998 Cancer Res. 58: 867–870
Kameda T, Watanabe H, Iba H . 1997 Cell Growth Differ. 8: 495–503,
Kataoka K, Noda M, Nishizawa M . 1994 Mol. Cell Biol. 14: 700–712
Kilbey A, Black EJ, Unlu M, Gillespie DA . 1996 Oncogene 12: 2409–2418
Kim S, Brown PH, Birrer MJ . 1996 Oncogene 12: 1043–1053
Kirch HC, Flaswinkel S, Rumpf H, Brockmann D, Esche H . 1999 Oncogene 18: 2728–2738
Kouzarides T, Ziff E . 1989 Nature 340: 568–571
Kralova J, Liss AS, Bargmann W, Bose Jr HR . 1998 Mol. Cell. Biol. 18: 2997–3009
Kruse U, Iacovoni JS, Goller ME, Vogt PK . 1997 Proc. Natl. Acad. Sci. USA 94: 12396–12400
Kumazaki T, Mitsui Y . 1996 Mech. Ageing Dev. 88: 111–124
Lallemand D, Spyrou G, Yaniv M, Pfarr CM . 1997 Oncogene 14: 819–830
Lamph WW, Wamsley P, Sassone-Corsi P, Verma IM . 1988 Nature 334: 629–631
Landschulz WH, Johnson PF, McKnight SL . 1988 Science 240: 1759–1764
Lavery DJ, Lopez-Molina L, Fleury-Olela F, Schibler U . 1997 Proc. Natl. Acad. Sci. USA 94: 6831–6836
Lee W, Haslinger A, Karin M, Tjian R . 1987a Nature 325: 368–372
Lee W. Mitchell P, Tjian R . 1987b Cell 49: 741–752
Liang P, Pardee AB . 1995 Curr. Opin. Immunol. 7: 274–280
Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF . 1999 Proc. Natl. Acad. Sci. USA 96: 4844–4849
Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M . 1995 Science 268: 286–290
Lin X, Gelman IH . 1997 Cancer Res. 57: 2304–2312
Lin X, Nelson P, Gelman IH . 2000 Mol. Cell. Biol. 20: 7259–7272
Lin X, Tombler E, Nelson PJ, Ross M, Gelman IH . 1996 J. Biol. Chem. 271: 28430–28438
Ljungdahl S, Linder S, Sollerbrant K, Svensson C, Shoshan MC . 1997 Eur. J. Biochem. 249: 648–656
Loftus TM, Nguyen YH, Stanbridge EJ . 1997 Biochemistry 36: 8224–8230
Maki Y, Bos TJ, Davis C, Starbuck M, Bogt PK . 1987 Proc. Natl. Acad. Sci. USA 84: 2848–2852
Marshall GM, Vanhamme L, Wong WY, Su H, Vogt PK . 1992 Virology 188: 373–377
Mattei MG, Simon-Chazottes D, Hirai S, Ryseck RP, Galcheva-Gargova Z, Guenet JL, Mattei JF, Bravo R, Yaniv M . 1990 Oncogene 5: 151–156
May GH, Allen KE, Clark W, Funk M, Gillespie DA . 1998a J. Biol. Chem. 273: 33429–33435
May GH, Funk M, Black EJ, Clark W, Hussain S, Woodgett JR, Gillespie DA . 1998b Curr. Biol. 8: 117–120
Mechta F, Lallemand D, Pfarr CM, Yaniv M . 1997 Oncogene 14: 837–847
Metivier C, Piu F, Pfarr CM, Yaniv M. Loiseau L, Castellazzi M . 1993 Oncogene 8: 2311–2315
Mettouchi A, Cabon F, Montreau N, Vernier P, Mercier G, Blangy D, Tricoire H, Vigier P, Binetruy B . 1994 EMBO J. 13: 5668–5678
Minden A, Karin M . 1997 Biochim. Biophys. Acta. 1333: F85–F104
Minden A, Lin A, Smeal T, Derijard B, Cobb M, Davis R, Karin M . 1994 Mol. Cell. Biol. 14: 6683–6688
Monteclaro FS, Vogt PK . 1993 Proc. Natl. Acad. Sci. USA 90: 6726–6730
Morgan IM, Asano M, Havarstein LS, Ishikawa H, Hiiragi T, Ito Y, Vogt PK . 1993 Oncogene 8: 1135–1140
Morgan IM, Havarstein LS, Wong WY, Luu P, Vogt PK . 1994 Oncogene 9: 2793–2797
Morgan IM, Ransone LJ, Bos TJ, Verma IM, Vogt PK . 1992 Oncogene 7: 1119–1125
Nakabeppu Y, Ryder K, Nathans D . 1998 Cell 55: 907–915
Neyns B, Teugels E, Bourgain C, Birrerand M, De Greve J . 1999 Int. J. Cancer 82: 687–693
Ng L, Forrest D, Curran T . 1993 Nucleic Acids. Res. 21: 5831–5837
Nika J, Erickson FL, Hannig EM . 1997 Yeast 13: 1155–1166
Nishimura T, Vogt PK . 1988 Oncogene 3: 659–636
Nishina H, Sato H, Suzuki T, Sato M, Iba H . 1990 Proc. Natl. Acad. Sci. USA 87: 3619–3623
Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S . 1989 Proc. Natl. Acad. Sci. USA 86: 7711–7715
Oberst C, Weiskirchen R, Hartl M, Bister K . 1997 Oncogene 14: 1109–1116
Oehler T, Pintzas A, Stumm S, Darling A, Gillespie D, Angel P . 1993 Oncogene 8: 1141–1147
Oliviero S, Robinson GS, Struhl K, Spiegelman BM . 1992 Genes Dev. 6: 1799–1809
Olman MA, Hagood JS, Simmons, WL, Fuller GM, Vinson C, White KE . 1999 Blood 94: 2029–2038
Pertovaara L, Sistonen L, Bos TJ, Vogt PK, Keski-Oja J, Alitalo K . 1989 Mol. Cell. Biol. 9: 1255–1262
Petrak D, Memon SA, Birrer MJ, Ashwell JD, Zacharchuk CM . 1994 J. Immunol. 153: 2046–2051
Pulverer BJ, Hughes K, Franklin CC, Kraft AS, Leevers SJ, Woodgett JR . 1993 Oncogene 8: 407–415
Qing J, Zhang Y, Derynck R . 2000 J. Biol. Chem. 275: 38802–38812
Ransone LJ, Visvader J, Lamph WW, Sassone-Corsi P, Verma IM . 1989a Int. J. Cancer. Suppl. 4: 10–21
Ransone LJ, Visvader J, Sassone-Corsi P, Verma IM . 1989b Genes Dev. 3: 770–781
Ransone LJ, Visvader J, Wamsley P, Verma IM . 1990a Proc.Natl. Acad. Sci. USA 87: 3806–3810
Ransone LJ, Wamsley P, Morley KL, Verma IM . 1990b Mol. Cell. Biol. 10: 4565–4573
Rao A . 1994 Immunol Today 15: 274–281
Rao A, Luo C, Hogan PG . 1997 Annu. Rev. Immunol. 15: 707–747
Rapp UR, Troppmair J, Beck T, Birrer MJ . 1994 Oncogene 9: 3493–3498
Rasmussen R, Benvegnu D, O'Shea EK, Kim PS, Alber T . 1991 Proc. Natl. Acad. Sci. USA 88: 561–564
Rauscher FJd, Cohen DR, Curran T, Bos TJ, Vogt PK, Bohmann D, Tjian R, Franza Jr BR . 1988 Science 240: 1010–1016
Rinaudo JA, Vacchiano E, Zelenka PS . 1995 J. Cell. Biochem. 58: 237–247
Rinehart-Kim J, Johnston M, Birrer M, Bos T . 2000 Int. J. Cancer 88: 180–190
Rittling SR, Coutinho L, Amram T, Kolbe M . 1989 Nucleic Acids Res. 17: 1619–1633
Ryder K, Lanahan A, Perez-Albuerne E, Nathans D . 1989 Proc. Natl. Acad. Sci. USA 86: 1500–1503
Ryder K, Lau LF, Nathans D . 1988 Proc. Natl. Acad. Sci. USA 85: 1487–1491
Ryseck RP, Hirai SI, Yaniv M, Bravo R . 1988 Nature 334: 535–537
Sassone-Corsi P, Lamph WW, Kamps M, Verma IM . 1988a Cell 54: 553–560
Sassone-Corsi P, Ransone LJ, Lamph WW, Verma IM . 1988b Nature 336: 692–695
Schaefer TS, Sanders LK, Nathans D . 1995 Proc. Natl. Acad. Sci. USA 92: 9097–9101
Scherer SJ, Maier SM, Seifert M, Hanselmann RG, Zang KD, Mueller-Hermelink HK, Angel P, Welter C, Schartl M . 2000 J. Biol. Chem. 12: 12
Schreiber M, Kolbus A, Piu F, Szabowski A, Mohle-Steinlein U, Tian J, Karin M, Angel P, Wagner EF . 1999 Genes Dev. 13: 607–619
Schuh AC, Keating SJ, Monteclaro FS, Vogt PK, Breitman ML . 1990 Nature 346: 756–760
Schule R, Rangarajan P, Kliewer S, Ranson LJ, Bolado J, Yang N, Verma IM, Evans RM . 1990 Cell 62: 1217–1226
Schutte J, Minna JD, Birrer MJ . 1989 Proc. Natl. Acad. Sci. USA 86: 2257–2261
Schuur ER, Kruse U, Iacovoni JS, Vogt PK . 1995 Cell Growth Differ. 6: 219–227
Schuur ER, Parker EJ, Vogt PK . 1993 Cell Growth Differ. 4: 761–768
Smeal T, Angel P, Meek J, Karin M . 1989 Genes Dev. 3: 2091–2100
Smeal T, Binetruy B, Mercola D, Grover-Bardwick A, Heidecker G, Rapp UR, Karin M . 1992 Mol. Cell. Biol. 12: 3507–3513
Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M . 1991 Nature 354: 494–496
Smith LM, Wise SC, Hendricks DT, Sabichi AL, Bos T, Reddy P, Brown PH, Birrer MJ . 1999 Oncogene 18: 6063–6070
Struhl K . 1987 Cell 50: 841–846
Su HY, Bos TJ, Monteclaro FS, Vogt PK . 1991 Oncogene 6: 1759–1766
Sutcliffe JG, Foye PE, Erlander MG, Hilbush BS, Bodzin LJ, Durham JT, Hasel KW . 2000 Proc. Natl. Acad. Sci. USA 97: 1976–1981
Suzuki T, Hashimoto Y, Okuno H, Sato H, Nishina H, Iba H . 1991 Jpn. J. Cancer Res. 82: 58–64
Suzuki T, Murakami M, Onai N, Fukuda E, Hashimoto Y, Sonobe MH, Kameda T, Ichinose M, Miki K, Iba H . 1994 J. Virol. 68: 3527–3535
Tagawa T, Kuroki T, Vogt PK, Chida K . 1995 J. Cell. Biol. 130: 255–263
Teurich S, Angel P . 1995 Chem. Senses 20: 251–255
Treier M, Staszewski LM, Bohmann D . 1994 Cell 78: 787–798
Turner R, Tjian R . 1989 Science 243: 1689–1694
Ubeda M, Vallejo M, Habener JF . 1999 Mol. Cell. Biol. 19: 7589–7599
Ui M, Mizutani T, Takada M, Arai T, Ito T, Murakami M, Koike C, Watanabe T, Yoshimatsu K, Iba H . 2000 Biochem. Biophys. Res. Commun. 278: 97–105
Ui M, Sonobe MH, Ito T, Murakami M, Okazaki S, Takada M, Sato T, Iba H . 1998 FEBS Lett. 429: 289–294
Usui H, Falk JD, Dopazo A, de Lecea L, Erlander MG, Sutcliffe JG . 1994 J. Neurosci. 14: 4915–4926
van Dam H, Huguier S, Kooistra K, Baguet J, Vial E, van der Eb AJ, Herrlich P, Angel P, Castellazzi M . 1998 Genes Dev. 12: 1227–1239
Vandel L, Montreau N, Vial E, Pfarr CM, Binetruy B, Castellazzi M . 1996 Mol. Cell. Biol. 16: 1881–1888
Vandel L, Pfarr CM, Huguier S, Loiseau L, Sergeant A, Castellazzi M . 1995 Oncogene 10: 495–507
Velculescu VE, Zhang L, Vogelstein B, Kinzler KW . 1995 Science 270: 484–487
Vial E, Castellazzi M . 2000 Oncogene 19: 1772–1782
Vial E, Perez S, Castellazzi M . 2000 Oncogene 19: 5020–5029
Vogt PK, Bos TJ, Doolittle RF . 1987 Proc. Natl. Acad. Sci. USA 84: 3316–3319
Wang N, Verna L, Hardy S, Zhu Y, Ma KS, Birrer MJ, Stemerman MB . 1999 Circ. Res. 85: 387–393
Watson A, Eilers A, Lallemand D, Kyriakis J, Rubin LL, Ham J . 1998 J. Neurosci. 18: 751–762
Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA . 1994 Proc. Natl. Acad. Sci. USA 91: 6030–6034
Wong C, Rougier-Chapman EM, Frederick JP, Datto MB, Liberati NT, Li JM, Wang XF . 1999 Mol. Cell. Biol. 19: 1821–1830
Wong WY, Havarstein LS, Morgan IM, Vogt PK . 1992 Oncogene 7: 2077–2080
Xanthoudakis S, Miao G, Wang F, Pan YC, Curran T . 1992 EMBO J. 11: 3323–3335
Xia Y, Wu Z, Su B, Murray B, Karin M . 1998 Genes Dev. 12: 3369–3381
Xiao L, Lang W . 2000 Cancer Res. 60: 400–408
Yang-Yen HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, Karin M . 1990 Cell 62: 1205–1215
Young MR, Li JJ, Rincon M, Flavell RA, Sathyanarayana BK, Hunziker R, Colburn N . 1999 Proc. Natl. Acad. Sci. USA 96: 9827–9832
Zhang W, Chen T, Wan T, He L, Li N, Yuan Z, Cao X . 2000 Biochem. Biophys. Res. Commun. 274: 872–879
Zhang X, Wrzeszczynska MH, Horvath CM, Darnell Jr JE . 1999 Mol. Cell. Biol. 19: 7138–7146
Zoumpourlis V, Papassava P, Linardopoulos S, Gillespie D, Balmain A, Pintzas A . 2000 Oncogene 19: 4011–4021
Acknowledgements
Research of the author is supported by grants from the National Cancer Institute, National Institutes of Health. Masa Aoki, Thorsten Berg, Weixing Chen, Jason Iacovoni, Barbara Kempf, Daniel Maslyar, Makoto Nishizawa, Corinna Sonderegger, Anke Waha and Mark Ware made valuable comments on the manuscript and generously tolerated the preoccupation of their mentor with this review. Special thanks are due to Anke Waha who compiled Table 1. This is manuscript number 13798-MEM from the Scripps Research Institute. This paper is dedicated to two charmingly independent and affectionate tabbies, Tampopo and Iris, who helped shorten and re-shorten the manuscript and the reference list.
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Vogt, P. Jun, the oncoprotein. Oncogene 20, 2365–2377 (2001). https://doi.org/10.1038/sj.onc.1204443
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DOI: https://doi.org/10.1038/sj.onc.1204443
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