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hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias

Oncogene volume 18, pages 5473–5476 (1999)Cite this article

Abstract

The role of oncogenes in pituitary tumorigenesis remains elusive since few genetic changes have been identified so far in pituitary tumors. Pituitary tumor-transforming gene (pttg) has been recently cloned from rat GH4 pituitary tumor cells. We have previously isolated and characterized hpttg from human thymus. In the present study, we analyse the expression of hpttg mRNA in a series of human pituitary adenomas. We show that hpttg is highly expressed in the majority of pituitary adenomas while only very low levels of mRNA can be detected in normal pituitary gland by Northern blot analysis. hPTTG protein was immunolocalized mainly in the cytoplasm of adenoma cells. Other common extra-cranial malignant tumors were also analysed by immunohistochemistry. Interestingly, strong hPTTG immunoreactivity was detected in most adenocarcinomas of mammary and pulmonary origins.

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Acknowledgements

We are grateful to Malcolm J Low for critical reading of the manuscript, and to the members of the Pituitary Tumors Collaborative Group (HUVR) for continuous support. This work was supported by grants from Ministerio de Educación y Ciencia of Spain (SAF96-0275), Fundación ANDEX (to C Sáez) and DGUI of the Junta de Andalucía.

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Author notes

  1. Carmen Sáez and Miguel A Japón: C Sáez and MA Japón contributed equally to this work

Authors and Affiliations

  1. Departamento de Anatomía Patológica, Hospital Universitario Virgen del Rocío, Sevilla, 41013, Spain

    Carmen Sáez, Miguel A Japón & Dolores I Segura

  2. Instituto de Recursos Naturales y Agrobiología, Apdo. 1052, Sevilla, 41080, Spain

    Francisco Ramos-Morales & José A Pintor-Toro

  3. Departamento de Microbiología, Facultad de Biología, Universidad de Sevilla, Apdo 1095, Sevilla, 41080, Spain

    Francisco Ramos-Morales, Francisco Romero & María Tortolero

Authors
  1. Carmen Sáez
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  2. Miguel A Japón
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  3. Francisco Ramos-Morales
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  6. María Tortolero
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  7. José A Pintor-Toro
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Sáez, C., Japón, M., Ramos-Morales, F. et al. hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias. Oncogene 18, 5473–5476 (1999). https://doi.org/10.1038/sj.onc.1202914

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