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Post-Transplant Complications

A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 31, pages 705–712 (2003)Cite this article

Summary:

Oral mucositis is a complication common to many cancer therapies and produces considerable pain and morbidity. The present study reports a double-blind, prospective, randomized clinical trial testing the efficacy of a calcium phosphate mouth rinse (Caphosol®) with fluoride treatments vs a standard regimen of fluoride rinsing and placebo tray treatments in 95 patients undergoing hematopoietic stem cell transplantation (HSCT). The days and severity of mucositis were prospectively evaluated. There were statistically significant decreases in days of mucositis (3.72 vs 7.22 P=0.001), duration of pain (2.86 vs 7.67, P=0.0001), dose of morphine (34.54 mg vs 122.78 mg), days of morphine (1.26 vs 4.02, P=0.0001) and days to the onset of engraftment ANC (absolute neurotrophil count)>200 mm3 (11.12 vs 12.56) in the Caphosol® and fluoride treatment group vs fluoride-rinse group, respectively. Caphosol®, a neutral, supersaturated, Ca2+/PO43− mouth rinse, used in combination with topical fluoride treatments, is superior to fluoride rinse alone in reducing the frequency, intensity and duration of oral mucositis in patients undergoing HSCT.

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Acknowledgements

We wish to acknowledge the following people: Dr Mabi Singh, Kathy Stack, Pamela Corrado and Dorothy Harrington of Tufts University School of Dental Medicine, Denise Hawe, Deb Mogavero, Irene Heffernan, Valerie Relias and Alanna Klekar of the Bone Marrow Transplant Unit and the nurses of North 8 of New England Medical Center for their assistance in the completion of this report.

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Authors and Affiliations

  1. Department of Oral Medicine, Tufts-New England Medical Center, Tufts University School of Dental Medicine, Boston, MA, USA

    A S Papas, R E Clark, G Martuscelli, K T O'Loughlin & E Johansen

  2. The Bone Marrow Transplant Unit, The New England Medical Center, Boston, MA, USA

    K B Miller

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Papas, A., Clark, R., Martuscelli, G. et al. A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant 31, 705–712 (2003). https://doi.org/10.1038/sj.bmt.1703870

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