Abstract
Pro-inflammatory (IL-6, TNFα and IL-8) and anti-inflammatory (IL-10) cytokines were determined in weekly samples from 52 patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). IL-6 increased immediately after transplant peaking at week +3, but IL-8 concentrations were elevated only during week +1. After a slight decrease in week +1, TNF-α significantly increased from week +2 and peaked at week +3, whereas, IL-10 values started to rise in week +2 and peaked during week +4. IL-6 and TNF-α were positively correlated from week +2 to week +4, and IL-6 levels at week +1 were related with fever and severe stomatitis. Serum levels of IL-6 at week +1 and IL-10 at week +4 were significantly higher in patients with early transplant-related complications, such as fever, severe stomatitis or acute GVHD ⩾ overall grade II than in those without the complications. We conclude that a high serum IL-6 level at week +1 may be an early predictor of transplant-related complications and that it seems to trigger pro- and anti-inflammatory cytokine release. Kinetic patterns of IL-6 and IL-10 were more exaggerated in those with complications after HSCT. Bone Marrow Transplantation (2001) 28, 935–940.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Antin JH, Ferrara LM . Cytokine dysregulation and acute graft-versus-host disease Blood 1992 80: 2964–2968
Ferrà C, de Sanjosé S, Gallardo D et al. IL-6 and IL-8 levels in serum during hematopoietic progenitor transplantation Haematologica 1998 83: 1082–1087
Remberger M, Ringdén O . Serum levels of cytokines after bone marrow transplantation: increased IL-8 levels during severe veno-occlusive disease of the liver Eur J Haematol 1997 59: 254–262
Imamura M, Hashino S, Kobayashi H et al. Serum cytokine levels in bone marrow transplantation: synergistic interaction of interleukin-6, interferon-γ, and tumor necrosis factor-α in graft-versus-host disease Bone Marrow Transplant 1994 13: 745–751
Schwaighofer H, Herold M, Schwarz T et al. Serum levels of interleukin 6, interleukin 8, and C-reactive protein after human allogeneic bone marrow transplantation Transplantation 1994 58: 430–436
Holler E, Kolb HJ, Möller A et al. Increased serum levels of tumor necrosis factor α precede major complications of bone marrow transplantation Blood 1990 75: 1011–1016
Moore KW, O'Garra A, de Waal Malefyt R et al. Interleukin-10 Annu Rev Immunol 1993 11: 165–190
de Waal Malefyt R, Yssel H, de Vries JE . Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation J Immunol 1993 150: 4754–4765
Holler E, Roncarolo MG, Hintermeier-Knabe R et al. Prognostic significance of IL-10 production in patients prior to allogeneic bone marrow transplantation Bone Marrow Transplant 2000 25: 237–241
Baker KS, Roncarolo M-G, Peters C et al. High spontaneous IL-10 production in unrelated bone marrow transplant recipients is associated with fewer transplant-related complications and early deaths Bone Marrow Transplant 1999 23: 1123–1129
Nash RA, Antin JH, Karanes C et al. Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors Blood 2000 96: 2062–2068
Glucksberg H, Storb R, Fefer A et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors Transplantation 1974 18: 295–304
McDonald GB, Sharma P, Matthews DE et al. Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors Hepatology 1984 4: 116–122
McDonald GB, Hinds MS, Fisher LD et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients Ann Intern Med 1993 118: 255–267
Chasty RC, Lamb WR, Gallati H et al. Serum cytokine levels in patients undergoing bone marrow transplantation Bone Marrow Transplant 1993 12: 331–336
Castell JV, Gomez-Lechon MJ, David M et al. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes FEBS Lett 1989 242: 237–239
Wanidworanun C, Strober W . Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis J Immunol 1993 151: 6853–6861
Takatsuka H, Takemoto Y, Okamoto T et al. Predicting the severity of graft-versus-host disease from interleukin-10 levels after bone marrow transplantation Bone Marrow Transplant 1999 24: 1005–1007
Hempel L, Körholz D, Nußbaum P et al. High interleukin-10 serum levels are associated with fatal outcome in patients after bone marrow transplantation Bone Marrow Transplant 1997 20: 365–368
Castenskiold EC, Kelsey SM, Collins PW et al. Functional hyperactivity of monocytes after bone marrow transplantation: possible relevance for the development of post-transplant complications or relapse Bone Marrow Transplant 1995 15: 879–884
Uguccioni M, Meliconi R, Nesci S et al. Elevated interleukin-8 serum concentrations in beta-thalassemia and graft-versus-host disease Blood 1993 81: 2252–2256
Steffen M, Dürken M, Pichlmeier U et al. Serum interleukin-6 levels during bone marrow transplantation: impact on transplant-related toxicity and engraftment Bone Marrow Transplant 1996 18: 301–307
Acknowledgements
We thank Dr Young-Hoon Suh (Hyundai Research Institute, Hyundai Pharmaceutical Co., Incheon, Korea) for cytokine measurements and also RN Hae-Keun Yoo and nursing staff at the BMT unit for their continual and generous support for our work. This work was supported by a grant from the Korean Ministry of Health and Welfare (HMP-98-M-1–0003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Min, CK., Lee, W., Min, DJ. et al. The kinetics of circulating cytokines including IL-6, TNF-α, IL-8 and IL-10 following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 28, 935–940 (2001). https://doi.org/10.1038/sj.bmt.1703258
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1703258
Keywords
This article is cited by
-
Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation
Cellular & Molecular Immunology (2021)
-
Assessment of a multi-cytokine profile by a novel biochip-based assay allows correlation of cytokine profiles with clinical outcomes in adult recipients of umbilical cord blood transplantation
Bone Marrow Transplantation (2020)
-
A preclinical acute GVHD mouse model based on chemotherapy conditioning and MHC-matched transplantation
Bone Marrow Transplantation (2016)
-
Low-level laser therapy prevents severe oral mucositis in patients submitted to hematopoietic stem cell transplantation: a randomized clinical trial
Supportive Care in Cancer (2016)
-
Ferritin as an early marker of graft rejection after allogeneic hematopoietic stem cell transplantation in pediatric patients
Annals of Hematology (2016)