Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Miscellaneous Complications

Risk factors for severe hemorrhagic cystitis following BMT

Abstract

Hemorrhagic cystitis (HC) is a common toxicity of preparative regimens for bone marrow transplantation (BMT). Severe HC often requires prolonged and expensive hospitalization, and occasionally can result in death. To investigate the risk factors for severe HC, we conducted a retrospective study among 1908 patients who received BMTs at the University of Minnesota during 1974 to 1993. A previous report from our institution reported on 977 of these patients. We identified all patients with genitourinary complication within 100 days post-BMT from the BMT database. Medical charts for these patients were reviewed to determine whether the patient had HC and also the grade of HC. A total of 208 HC cases were identified during the study period. Of them, 92 patients had severe HC, an incidence of 5% (95% CI = 4–6%). We found that grade II–IV graft-versus-host disease (RR = 2.56; 95% CI = 1.43–4.56), use of busulfan (RR = 2.69; 95% CI = 1.35–5.35), and age at transplant (RR = 2.20; 95% CI = 1.27–3.81, for age of 10–30 compared to age of 0–9) were related to an increased risk of HC. In contrast, transplant year was inversely associated with the risk of HC (trend test, P < 0.01). we did not find any significant difference in hc with the use of prophylactic mesna.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Seber, A., Shu, X., Defor, T. et al. Risk factors for severe hemorrhagic cystitis following BMT. Bone Marrow Transplant 23, 35–40 (1999). https://doi.org/10.1038/sj.bmt.1701523

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1701523

Keywords

This article is cited by

Search

Quick links