Macrodomains function as binding modules for metabolites of NAD+, including poly(ADP-ribose). Three new studies explore how binding of poly(ADP-ribose) by the macrodomains of histone variant macroH2A1.1 and the ATP-dependent chromatin-remodeling protein ALC1 (also called CHD1L) leads to the modulation of chromatin structure, regulating nuclear functions such as DNA-damage detection and repair.
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Kraus, W. New functions for an ancient domain. Nat Struct Mol Biol 16, 904–907 (2009). https://doi.org/10.1038/nsmb0909-904
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DOI: https://doi.org/10.1038/nsmb0909-904
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