Neuroendocrine prostate cancer (NEPC) is commonly associated with aggressive clinical features and poor overall survival. Now, an integrated analysis of data from prostate cancer transcriptomics and genetically modified mouse models reveals that overexpression of the N-Myc proto-oncogene leads to the development of prostate cancer with a phenotype similar to that of NEPC. Researchers also demonstrated that N-Myc expression abrogates androgen sensitivity, a hallmark of NEPC; however, cellular models of N-Myc overexpression were also sensitized to aurora kinase A inhibition with MLN8237.
References
Dardenne, E. et al. N-Myc induces an EZH2-mediated transcriptional program driving neuroendocrine prostate cancer. Cancer Cell 30, 563–577 (2016)
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Sidaway, P. N-Myc expression drives neuroendocrine disease. Nat Rev Urol 13, 695 (2016). https://doi.org/10.1038/nrurol.2016.218
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DOI: https://doi.org/10.1038/nrurol.2016.218
