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Metaplastic breast carcinoma: more than a special type

Nature Reviews Cancer volume 14, pages 147–148 (2014)Cite this article

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Abstract

Metaplastic breast carcinoma (MBC) is a special histological type of invasive breast cancer. MBC is a descriptive and operational term for a heterogeneous collection of tumours with distinct histologies, clinical behaviours and potentially responses to therapy.

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Figure 1: The phenotypical diversity of metaplastic breast cancers.

References

  1. Lakhani, S. R., et al. WHO Classification of Tumours of the Breast, Fourth Edition (IARC, 2012).

    Google Scholar 

  2. Hennessy, B. T. et al. Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res. 69, 4116–4124 (2009).

    Article  CAS  Google Scholar 

  3. Lien, H. C. et al. p53 overexpression and mutation in metaplastic carcinoma of the breast: genetic evidence for a monoclonal origin of both the carcinomatous and the heterogeneous sarcomatous components. J. Pathol. 204, 131–139 (2004).

    Article  CAS  Google Scholar 

  4. Weigelt, B., Kreike, B. & Reis-Filho, J. S. Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysis. Breast Cancer Res. Treat. 117, 273–280 (2009).

    Article  CAS  Google Scholar 

  5. Ince, T. A. et al. Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell 12, 160–170 (2007).

    Article  CAS  Google Scholar 

  6. Molyneux, G. et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7, 403–417 (2010).

    Article  CAS  Google Scholar 

  7. Liu, X. et al. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc. Natl Acad. Sci. USA 104, 12111–12116 (2007).

    Article  CAS  Google Scholar 

  8. Hayes, M. J., Thomas, D., Emmons, A., Giordano, T. J. & Kleer, C. G. Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast. Clin. Cancer Res. 14, 4038–4044 (2008).

    Article  CAS  Google Scholar 

  9. Lacroix-Triki, M. et al. β-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast. Mod. Pathol. 23, 1438–1448 (2010).

    Article  CAS  Google Scholar 

  10. Geyer, F. C. et al. Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas. J. Pathol. 220, 562–573 (2010).

    Article  CAS  Google Scholar 

  11. Reis-Filho, J. S. et al. EGFR amplification and lack of activating mutations in metaplastic breast carcinomas. J. Pathol. 209, 445–453 (2006).

    Article  CAS  Google Scholar 

  12. Turner, N. C. et al. BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene 26, 2126–2132 (2007).

    Article  CAS  Google Scholar 

  13. Sproul, D. et al. Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer. Proc. Natl Acad. Sci. USA 108, 4364–4369 (2011).

    Article  CAS  Google Scholar 

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Author notes

  1. Britta Weigelt, Carey Eberle, Catherine F. Cowell and Charlotte K. Y. Ng: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, 10065, New York, USA

    Britta Weigelt, Carey Eberle, Catherine F. Cowell, Charlotte K. Y. Ng & Jorge S. Reis-Filho

Authors
  1. Britta Weigelt
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  2. Carey Eberle
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  3. Catherine F. Cowell
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  4. Charlotte K. Y. Ng
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  5. Jorge S. Reis-Filho
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Corresponding author

Correspondence to Jorge S. Reis-Filho.

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The authors declare no competing financial interests.

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Weigelt, B., Eberle, C., Cowell, C. et al. Metaplastic breast carcinoma: more than a special type. Nat Rev Cancer 14, 147–148 (2014). https://doi.org/10.1038/nrc3637

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