COX-2 selective non-steroidal anti-inflammatory drugs show promise in the prevention of coiorectal cancer and possibly other tumors.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Increased NF-κB DNA binding but not transcriptional activity during apoptosis induced by the COX-2-selective inhibitor NS-398 in colorectal carcinoma cells
British Journal of Cancer Open Access 30 September 2003
-
Aspirin induces cell death and caspase-dependent phosphatidylserine externalization in HT-29 human colon adenocarcinoma cells
British Journal of Cancer Open Access 27 August 1999
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Shift, S.J. & Rigas, B. Nonsteroidal antiinflamma-tory drugs and colorectal cancer: evolving concepts of their chemopreventive actions. Gastroenterology 113 1992–1998 (1997).
Kawamori, T., Rao, C.V., Seibert, K. & Reddy, B.S. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res. 58, 409–412 (1998).
Williams, C.S. & DuBois, R.N. Prostaglandin endoperoxide synthase: Why two isoforms? Am. J. Physiol 270, G393–G400 (1996).
Oshima, M. et al. Suppression of intestinal polyposis in ApcΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87, 803–809 (1996).
Sheng, H., Shao, J., Morrow, J.D., Beauchamp, R.D. & DuBois, R.N. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res. 58, 362–366 (1998).
Chan, T.A., Morin, P.J., Vogelstein, B. & Kinzler, K.W. Mechanisms underlying nonsteroidal anti-inflammatory drug-mediated apoptosis. Proc. Natl. Acad. Sci. USA 95, 681–686 (1998).
Piazza, G.A. et al. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. Cancer Res. 57, 2909–2915 (1997).
Elder, D.J.E., Halton, D.E., Hague, A. & Paraskeva, C. Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression. Clin. Can. Res. 3, 1679–1683 (1997).
Vane, J. Towards a better aspirin. Nature 367, 215–216 (1994).
Hong, S.H. et al. Regulation of head and neck tumor cell growth with cyclooxygenase-2 specific inhibitor, ketorolac. Cancer Res. 39, 196 (1998).
Hwang, D. et al. Expression of cyclooxygenase in human breast cancer. Cancer Res. 39, 353 (1998).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Elder, D., Paraskeva, C. COX-2 inhibitors for colorectal cancer. Nat Med 4, 392–393 (1998). https://doi.org/10.1038/nm0498-392
Issue Date:
DOI: https://doi.org/10.1038/nm0498-392
This article is cited by
-
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2
Nature Medicine (2011)
-
The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells
Oncogene (2010)
-
Celecoxib disrupts the canonical apoptotic network in HTLV-I cells through activation of Bax and inhibition of PKB/Akt
Apoptosis (2008)
-
Increased NF-κB DNA binding but not transcriptional activity during apoptosis induced by the COX-2-selective inhibitor NS-398 in colorectal carcinoma cells
British Journal of Cancer (2003)
-
Relationship between APC genotype, polyp distribution, and oral sulindac treatment in the colon and rectum of patients with familial adenomatous polyposis
Diseases of the Colon & Rectum (2001)