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New strategies of DLI in the management of relapse of hematological malignancies after allogeneic hematopoietic SCT

Bone Marrow Transplantation volume 51, pages 324–332 (2016)Cite this article

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Abstract

DLI is an effective strategy for patients with recurrent hematological malignancies after allogeneic hematopoietic SCT (allo-HSCT). DLI has been widely applied to boost the graft vs tumor (GVT) or GVL effects. However, given the potentially severe complications associated with conventional DLI and transient GVL effect, new strategies for DLI are emerging. In this review, we have discussed the recent important studies on DLI as a prophylactic or therapeutic modality for relapsed hematological disorders after allo-HSCT. The strategies to separate GVL from GVHD have also been discussed. Leukemia-targeting therapy and lymphodepletion combined with DLI, and prophylactic DLI after allo-HSCT are often employed for patients with high risk of relapse, which has been reviewed as well. In addition, we have also discussed the issues on DLI to be further addressed, such as the doses, timing and frequency of DLI in different clinical settings, leukemic antigen-specific DLI as well as how to augment GVL effect while attenuating GVHD.

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Acknowledgements

We thank Dr Xiao-Jun Huang at the Hematopoietic Stem Cell Transplantation Center, Institute of Hematology, Peking University Health Science Center for critically reading our manuscript and providing the very helpful discussions and suggestions on this manuscript. This work was supported by the grant from the Natural Science Foundation of China (No. 81172854 & No. 81240015).

Author contributions

XC wrote the paper, XZ helped organize and edit the paper and CQX proposed the project and edited the paper.

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Authors and Affiliations

  1. Department of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, China

    X Chang & C-Q Xia

  2. Intensive Care Unit, Beijing Shijitan Hospital, Capital Medical University, Beijing, China

    X Zang

  3. Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA

    C-Q Xia

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  1. X Chang
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  2. X Zang
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  3. C-Q Xia
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Correspondence to C-Q Xia.

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Chang, X., Zang, X. & Xia, CQ. New strategies of DLI in the management of relapse of hematological malignancies after allogeneic hematopoietic SCT. Bone Marrow Transplant 51, 324–332 (2016). https://doi.org/10.1038/bmt.2015.288

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