Abstract
Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo.
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Acknowledgements
We thank H. Ananthaswamy and L. Owen-Schaub for critically reviewing this manuscript and L. Van Kaer for providing inbred CD1-deficient and WT mice. Supported by grants from the NIH (CA75575 and ES07327). The animal facilities at UT MDACC are supported in part by a NCI Core Grant (CA16672).
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Moodycliffe, A., Nghiem, D., Clydesdale, G. et al. Immune suppression and skin cancer development: regulation by NKT cells . Nat Immunol 1, 521–525 (2000). https://doi.org/10.1038/82782
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DOI: https://doi.org/10.1038/82782
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