The first Phase II clinical trial to study the combination of a replicating viral agent with chemotherapy indicates that cancer gene therapy may finally be on the road to success. ( 879–885).
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References
Khuri, F.R. et al. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nature Med. 6, 879–885 (2000).
Barker, D.D. & Berk, A.J. Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection. Virology 156, 107– 121 (1987).
Yew, P.R & Berk, A.J. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357, 82–83 ( 1992).
Heise, C. et al. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nature Med. 3, 639– 645 (1997).
Rosenberg, S.A. et al. Gene transfer into humans – immunotherapy of patients with advanced melanoma, suing tumor-infiltrating lymphocytes modified by retroviral gene transduction. N. Engl. J. Med. 323, 570–578 (1990).
Blaese, R.M. et al. T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years. Science 270, 475–480 (1995).
Kay, M.A. et al. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nature Genet. 24, 257–261 (2000).
Isner, J.M. & Asahara, T. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J. Clin. Invest. 103, 1231–1266 (1999).
Cavazzana-Calvo, M. et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288, 669– 672 (2000)
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Anderson, W. Gene therapy scores against cancer. Nat Med 6, 862–863 (2000). https://doi.org/10.1038/78610
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DOI: https://doi.org/10.1038/78610