Lack of oxygen induces the death of cells at the centre of tumours. But cells with mutations in the p53 tumour suppressor can survive such conditions, providing yet another lead in the study of this notorious gene.
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Altered gene expression and miRNA expression associated with cancerous IEC-6 cell transformed by MNNG
Journal of Experimental & Clinical Cancer Research Open Access 28 April 2009
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Kinzler, K., Vogelstein, B. Life (and death) in a malignant tumour. Nature 379, 19–20 (1996). https://doi.org/10.1038/379019a0
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DOI: https://doi.org/10.1038/379019a0
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