Abstract
Tubulin synthesis in animal cells is controlled by an autoregulatory mechanism that modulates the stability of polysome-bound tubulin messenger RNAs. The β-tubulin RNAs are selectively targeted as substrates for destabilization not through the recognition of specific RNA sequences, but rather through co-translational recognition of the amino-terminal β-tubulin tetrapeptide after its emergence from the ribosome. This motif is likely to be used in other systems where RNA degradation is coupled to ribosome attachment and translation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cleveland, D. W. J. Cell Biol. 104, 381–383 (1987).
Cleveland, D. W., Lopata, M. A., Sherline, P. & Kirschner, M. W. Cell 25, 537–546 (1981).
Caron, J. M., Jones, A. L., Rall, L. B. & Kirschner, M. W. Nature 317, 648–650 (1985).
Caron, J. M., Jones, A. L. & Kirschner, M. W. J. Cell Biol. 101, 1763–1772 (1985).
Pittenger, M. F. & Cleveland, D. W. J. Cell Biol. 101, 1941–1952 (1985).
Gay, D. A., Yen, T. J., Lau, J. T. Y. & Cleveland, D. W. Cell 50, 671–679 (1987).
Yen, T. J., Gay, D. A., Pachter, J. S. & Cleveland, D. W. Molec. cell. Biol. 8, 1224–1235 (1988).
Bird, R. C., Jacobs, F. A. & Sells, B. H. Biochem. Cell Biol. 64, 99–105 (1986).
Graves, R. A., Pandey, N. B., Chodchoy, N. & Marzluff, W. F. Cell 48, 795–804 (1987).
Linial, M., Gunderson, N. & Groudine, M. Science 230, 1126–1131 (1985).
Kruijer, W., Cooper, J. A., Hunter, T. & Verma, I. Nature 312, 711–716 (1984).
Miller, A. D., Curran, T. & Verma, I. Cell 36, 51–60 (1984).
Muller, R., Bravo, R., Burckhardt, J. & Curran, T. Nature 312, 716–720 (1984).
Shaw, G. & Kamen, R. Cell 46, 659–667 (1986).
Treisman, R. Cell 42, 889–902 (1985).
Pachter, J. S., Yen, T. J. & Cleveland, D. W. Cell 51, 283–292 (1987).
Lee, M. G.-S., Lewis, S. A., Wilde, C. D. & Cowan, N. J. Cell 33, 477–486 (1983).
Zoller, M. J. & Smith, M. Meth. Enzym. 100, 468–500 (1983).
Lau, J. T. Y., Pittenger, M. F. & Cleveland, D. W. Molec. cell. Biol. 5, 1611–1620 (1985).
Yonath, A., Leonard, K. R. & Wittman, H. G. Science 236, 813–816 (1987).
Capasso, O., Bleeker, G. C. & Heintz, N. EMBO J. 6, 1825–1831 (1987).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yen, T., Machlin, P. & Cleveland, D. Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin. Nature 334, 580–585 (1988). https://doi.org/10.1038/334580a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/334580a0
This article is cited by
-
Functional Investigation of TUBB4A Variants Associated with Different Clinical Phenotypes
Molecular Neurobiology (2022)
-
Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes
Scientific Reports (2020)
-
Genetics in Dystonia: An Update
Current Neurology and Neuroscience Reports (2013)
-
The effect of griseofulvin on the gene regulation of β-tubulin in the dermatophyte pathogen Trichophyton rubrum
Journal of Infection and Chemotherapy (2007)
-
Cloning and Characterization of a ?3 Tubulin cDNA From the Small Brown Planthopper, Laodelphax striatellus
Biochemical Genetics (2005)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.