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Induction of c-fos gene and protein by growth factors precedes activation of c-myc

Abstract

Stimulation of fibroblasts with serum or purified growth factors leads to a dramatic induction of expression of both c-fos mRNA and protein within a few minutes, followed by activation of c-myc. This suggests that c-fos induction is a primary event and the earliest known effect on gene expression by growth factors.

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Müller, R., Bravo, R., Burckhardt, J. et al. Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature 312, 716–720 (1984). https://doi.org/10.1038/312716a0

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