Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Human chorionic gonadotropin β-subunit is encoded by at least eight genes arranged in tandem and inverted pairs

Abstract

The β-subunit of the human placental glycoprotein hormone, chorionic gonadotropin (HCG), is coded for by at least eight different genes or pseudogenes, four of which are arranged in inverted pairs while the other four are arranged in tandem pairs. The genes are each 1.45 kilobases (kb) long and have two short introns located in identical positions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Pierce, J. G. & Parsons, T. F. A. Rev. Biochem. 50, 465–495 (1981).

    Article  CAS  Google Scholar 

  2. Fiddes, J. C. & Goodman, H. M. Nature 281, 351–356 (1979).

    Article  CAS  ADS  Google Scholar 

  3. Fiddes, J. C. & Goodman, H. M. Nature 286, 684–687 (1980).

    Article  CAS  ADS  Google Scholar 

  4. Fiddes, J. C. & Goodman, H. M. J. molec. appl. Genet. 1, 3–18 (1981).

    CAS  Google Scholar 

  5. Boothby, M., Ruddon, R. W., Anderson, C., McWilliams, D. & Boime, I. J. biol. Chem. 265, 5121–5127 (1981).

    Google Scholar 

  6. Lawn, R. M., Fritsch, E. F., Parker, R. C., Blake, G. & Maniatis, T. Cell 15, 1157–1174 (1981).

    Article  Google Scholar 

  7. Southern, E. M. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  Google Scholar 

  8. Jones, C. W. & Kafatos, F. C. Nature 284, 635–637 (1980); Cell 22, 855–867 (1980).

    Article  CAS  ADS  Google Scholar 

  9. Harvey, R. P., Krieg, P. A., Robins, J., Coles, L. S. & Wells, J. R. E. Nature 294, 49–53 (1981).

    Article  CAS  ADS  Google Scholar 

  10. Synder, M. et al. Cell 29, 1027–1040 (1982).

    Article  Google Scholar 

  11. Franchimont, P., Gaspard, V., Reuter, A. & Heynen, G. Clin. Endocr. 1, 315–316 (1973).

    Article  Google Scholar 

  12. Rigby, P. W. J., Dieckmann, M., Rhodes, C. & Berg, P. J. molec. Biol. 113, 237–251 (1977).

    Article  CAS  Google Scholar 

  13. Taylor, J. M., Illemensee, R. & Summers, S. Biochim. biophys. Acta 442, 324–330 (1976).

    Article  CAS  Google Scholar 

  14. Benton, W. D. & Davis, R. W. Science 196, 180–182 (1977).

    Article  CAS  ADS  Google Scholar 

  15. Maxam, A. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Boorstein, W., Vamvakopoulos, N. & Fiddes, J. Human chorionic gonadotropin β-subunit is encoded by at least eight genes arranged in tandem and inverted pairs. Nature 300, 419–422 (1982). https://doi.org/10.1038/300419a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/300419a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing