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Mutations affecting segment number and polarity in Drosophila

Abstract

In systematic searches for embryonic lethal mutants of Drosophila melanogaster we have identified 15 loci which when mutated alter the segmental pattern of the larva. These loci probably represent the majority of such genes in Drosophila. The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.

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References

  1. Lohs-Schardin, M., Cremer, C. & Nüsslein-Volhard, C. Devl. Biol. 73, 239–255 (1979).

    Article  CAS  Google Scholar 

  2. Wieschaus, E. & Gehring, W. Devl. Biol. 50, 249–263 (1976).

    Article  CAS  Google Scholar 

  3. Nüsslein-Volhard, C. in Determinants of Spatial Organisation (eds Subtelney, S. & Konigsberg, I. R.) 185–211 (Academic, New York, 1979).

    Book  Google Scholar 

  4. Sander, K. Adv. Insect Physiol. 12, 125–238 (1976).

    Article  Google Scholar 

  5. Lewis, E. B. Nature 276, 565–570 (1978).

    Article  ADS  CAS  Google Scholar 

  6. Garcia-Bellido, A. Am. Zool. 17, 613–629 (1977).

    Article  Google Scholar 

  7. Szabad, J., Schüpbach, T. & Wieschaus, E. Devl. Biol. 73, 256–271 (1979).

    Article  CAS  Google Scholar 

  8. Counce, S. Z. Induktive Abstammungs-Vererbungslehre 87, 462–81 (1958).

  9. Sharma, R. P. & Chopra, V. L. Devl Biol. 48, 461–465 (1976).

    Article  CAS  Google Scholar 

  10. Lawrence, P. A. & Morata, G. Devl Biol. 50, 321–337 (1976).

    Article  CAS  Google Scholar 

  11. Kornberg, T., in preparation.

  12. Gloor, H. Arch. Julius-Klaus-Stift. VererbForsch 25, 38–44 (1950).

    Google Scholar 

  13. Meinhardt, H. J. Cell Sci. 23, 117–139 (1977).

    Google Scholar 

  14. Bryant, P. J. Ciba Fdn Symp. 29, 71–93 (1975).

    Google Scholar 

  15. Wright, D. & Lawrence, P. A., in preparation.

  16. Lawrence, P. A. in Developmental Systems: Insects (eds Counce, S. & Waddington, C. H.) 157–209 (Academic, London, 1973).

    Google Scholar 

  17. Jürgens, G. & Gateff, E. Wilhelm Roux Arch. 186, 1–25 (1979).

    Article  Google Scholar 

  18. Meinhardt, H. & Gierer, A. J. Cell. Sci. 15, 321–346 (1974).

    CAS  PubMed  Google Scholar 

  19. Kaufmann, S. A., Shymko, R. M. & Trabert, K. Science 199, 259–270 (1978).

    Article  ADS  Google Scholar 

  20. Lindsley, D. & Grell, E. H. Genetic Variations of Drosophila melanogaster (Carnegie, Washington, 1968).

    Google Scholar 

  21. Wright, T. R. F. Drosoph. Inf. Serv. 45, 140 (1970).

    Google Scholar 

  22. Vander Meer, J. Drosoph. Inf. Serv. 52, 160 (1977).

    Google Scholar 

Download references

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Nüsslein-Volhard, C., Wieschaus, E. Mutations affecting segment number and polarity in Drosophila. Nature 287, 795–801 (1980). https://doi.org/10.1038/287795a0

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