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Msx-1 and Msx-2 in Mammary Gland Development

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Abstract

Homeobox genes do not generally function alone to determine cell fate and morphogenesis. Rather it is the distinct combination of various members of the homeobox family of genes and their spatiotemporal patterns of expression that determine cell identity and function. Functional redundancy often makes it difficult to clearly discern the role of any one given homeobox gene. The roles that Msx1 and Msx2 play in branching morphogenesis of the mammary gland are only now becoming more evident. Many signaling pathways and transcription factors are implicated in how these homeobox genes correctly determine the morphological development of the gland. Overexpression of Msx1 and Msx2 may also be involved in tumorigenesis. Additional studies are needed to elucidate the roles of these genes in both breast development and cancer.

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  1. Molecular and Cellular Endocrinology Section, Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

    Kennichi Satoh, Erika Ginsburg & Barbara K. Vonderhaar

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  1. Kennichi Satoh
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Satoh, K., Ginsburg, E. & Vonderhaar, B.K. Msx-1 and Msx-2 in Mammary Gland Development. J Mammary Gland Biol Neoplasia 9, 195–205 (2004). https://doi.org/10.1023/B:JOMG.0000037162.84758.b5

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