Research ArticleTargeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells
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List of abbreviations
Gb3
Globotriaosylceramide
GCS
Glucosylceramide synthase
GSL
Glycosphingolipid
MDR1
Multidrug resistance 1/P-glycoprotein
MPM
Malignant pleural mesothelioma (MPM)
MRP1
Multidrug resistance-associated protein 1
NSCLC
Non-small cell lung cancer
PPMP
DL-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol
Keywords
Cisplatin
Glucosylceramide synthase (GCS)
Globotriaosylceramide (Gb3)
Lung cancer
Multidrug resistance 1/P-glycoprotein (MDR1)
Multidrug resistance-associated protein 1 (MRP1)
Malignant pleural mesothelioma (MPM)
DL-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP)
Cyclosporin A
Acquired drug resistance
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Copyright © 2015 The Authors. Published by Elsevier Inc.