Basic and Translational ScienceCirculating Tumor M2 Pyruvate Kinase and Thymidine Kinase 1 Are Potential Predictors for Disease Recurrence in Renal Cell Carcinoma After Nephrectomy
Section snippets
Study Patients
In this prospective study we included patients with renal masses scheduled for nephrectomy (either radical or nephron-sparing), older than 18 years, with clinical stage T3cN0M0 or less. We also included patients with known metastatic disease who were candidates for cytoreductive surgery with World Health Organization performance status 0-2 and 20 healthy individuals. A total of 163 persons (100 males and 63 females) were found to be eligible. Their characteristics, including histology of the
Results
There was no significant change in the distribution of age and gender between 3 groups: healthy, BKT and RCC (P = .1 and P = .39). Of the 116 patients with RCC, 107 patients had a localized or locally advanced tumor and underwent radical or partial nephrectomy with curative intent. They were followed after surgery for a median of 33 months (range, 1-110 months). The remaining 9 patients had metastatic disease at presentation and underwent cytoreductive nephrectomy. Median follow-up for these
Comment
Tumor cells release into circulation substances that may serve as tumor markers. Although various biomolecules have been tested in RCC none of them as of today appears useful. In this study we estimated the clinical value of 2 circulating biomarkers, TuM2-PK and TK1.
Previous studies have shown that plasma TuM2-PK levels in patients with malignant renal tumors were significantly higher than in healthy donors20 or in patients with benign urological conditions, such as benign prostatic hyperplasia
Conclusions
In conclusion, we found that 2 circulating markers, TuM2-PK and TK1, are capable of predicting disease recurrence in RCC patients after nephrectomy. The use of these 2 markers in combination enhanced the predictive power of testing. The preoperative measurements of TuM2-PK and TK1 may offer valuable prognostic information that can be used in stratification of patients in treatment planning after nephrectomy.
Acknowledgments
We thank Mario Baras of the Hebrew University, Hadassah School of Public Health, for advice on the statistical analysis.
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Relationship Between Thymidine Kinase 1 Expression and Trifluridine/Tipiracil Therapy in Refractory Metastatic Colorectal Cancer: A Pooled Analysis of 2 Randomized Clinical Trials
2018, Clinical Colorectal CancerCitation Excerpt :OS data in the patients receiving placebo indicated that high TK1 expression may be a marker of poor prognosis. Although similar findings have previously been reported in several cancers, there are no reports in CRC.23-25 Regarding the potential clinical utility of TK1 as a biomarker for FTD/TPI efficacy, a greater OS benefit was observed in patients with high TK1 expression receiving FTD/TPI at the 15% cutoff point, while PFS and DCR benefits in patients receiving FTD/TPI were similar between high and low TK1 expression subgroups.
Biomarkers of Renal Cancer
2017, Biomarkers of Kidney DiseaseThe multifaceted regulation and functions of PKM2 in tumor progression
2014, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :In addition, plasma PKM2 may be used as a marker in pancreatic, gastric, esophageal, cervical cancer, cholangiocellular cancer, renal cell carcinoma and melanoma [120–123]. Circulating PKM2 also shows a prognostic value for disease recurrence in renal cell carcinoma after nephrectomy [124] and death risk of colorectal cancer [125]. However, other researchers have reported that PKM2 may be not a good screening marker for colorectal cancer [126–130], oral squamous cell carcinoma [131], renal cell carcinoma [132], Barrett's adenocarcinoma [133], and hematological malignancies [134].
Nuclear PKM2 expression predicts poor prognosis in patients with esophageal squamous cell carcinoma
2013, Pathology Research and PracticeCitation Excerpt :However, we did not find any PKM2 expression in nucleus correlation with stages and lymph node metastasis, which could be relevant to the different expressions in varied tumor cells and different PKM2 tests. Many studies have shown that cytoplasmic PKM2 overexpression and/or increased plasma PKM2 were independent factors of poor prognosis in patients with cancer [13,17,19,46]. However, there are few reports on the relationship between nuclear PKM2 expression and human cancer.
Thymidine kinase and cancer monitoring
2012, Cancer LettersCitation Excerpt :Significantly higher levels of TuM2-PK and TK1 were found in patients with RCC compared with healthy participants (p < 0.001 and p = 0.03), but not compared with 27 patients with benign kidney tumors (p = 0.13 and p = 0.72). It could be shown that the 5-year recurrence-free survival for patients with elevated TK1 (or TuM2-PK) was significantly lower compared with those for patients with normal markers [31]. For a more detailed evidence and to clarify the role of TK1 in different types of RCC and oncocytoma a new proliferation antigen 210 (XPA-210) of TK1 was used.
Serum Concentration of Thymidine Kinase 1 (TK1) as a Tumor Marker in Soft Tissue Sarcomas
2022, Anticancer Research
B. Nisman and V. Yutkin contributed equally to this work.