Adult urologyProstate cancer in native Japanese and Japanese-American men: Effects of dietary differences on prostatic tissue
Section snippets
Material and methods
A retrospective study of 50 Japanese men undergoing radical prostatectomy for cure of localized CaP between 1994 and 2001 was performed. All 50 men had typical Japanese surnames, and each regarded himself as of pure Japanese ancestry. Of the 50 men, 25 were Japanese-born men undergoing surgery in Nagoya, Japan, and 25 were second-generation or third-generation American-born Japanese men undergoing surgery in Los Angeles, California. Each series was consecutive and included all qualifying
Clinical characteristics
The men in this study were mostly in their mid to late 60s with moderately differentiated, organ-confined CaP (Table I). The J-A men were, on average, 5 years older (70 years versus 65 years), had a greater percentage of body fat (24.2% versus 19.3%), and underwent surgery 28.2 months earlier than the NJ men (P <0.002). Otherwise, the two groups were similar in terms of prostate weight (38.5 to 34.8 g), serum prostate-specific antigen level (7.1 to 8.6 ng/mL), pathologic tumor stage (mostly
Comment
The main hypothesis of the present study was that Western diet leads to tissue changes associated with malignant transformation in the prostate. Thus, two groups of men were studied, all with CaP and all from the same gene pool (all Japanese), but ingesting diets traditionally known to be markedly different. Although the dietary questionnaire did not reveal dramatic differences between the NJ and J-A men, their body composition was found to be different in several important ways, and related
Acknowledgment
To Maria Luz Macairan, M.D., Arlyn Llanes, and Shamim Baker, who provided research coordination at the Urological Sciences Research Foundation; Matthew Putzi, M.D., Helen Fedor, and the staff at the Johns Hopkins Tissue Microarray Laboratory, who constructed the tissue microarray; Massood A. Khan of the Brady Urological Institute for performing the QNG image analysis; George Yamauchi, M.D., and Yuichi Ito, M.D., who contributed the Los Angeles patients from their urology practices; George
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This study was supported by grants from CaPCURE, The Prostate Cancer Foundation, Santa Monica, California; Elsa U. Pardee Foundation, Midland, Michigan; UCLA Clinical Nutrition Research Unit, grant CA 42170 to D. Heber; NCI grant P01-CA77739 to J. L. Mohler; Early Detection Research Network, NCI grant U01CA86323 and NCI Spore grant P50CA58236 to A. W. Partin.
This study was presented in part at the Annual Meeting of the American Urological Association, Chicago, Illinois, April, 2003, and at the Annual Retreat of the CaPCURE Foundation, Washington, DC, September 2002.