Altered growth patterns of colorectal liver metastases after thermal ablation
Section snippets
Animals
Male inbred CBA-strain mice, 6 to 8 weeks of age, were used. Animals were housed in standard cages with access to irradiated food and water ad libitum and exposed to a 12-hour light/dark cycle. All procedures were performed according to the guidelines of the Austin Hospital Animal Ethics Committee.
Liver metastases model
A dimethyl hydrazine–derived primary murine colon cancer cell line was used for the induction of colorectal liver metastases by methods described previously.10 The histology, vasculature, and growth
Extrahepatic metastases
All animals killed at 21 days after induction of metastases in treatment and control groups had liver metastases without evidence of extrahepatic spread.
Control animals
Macroscopically, there was homogenous spread of neoplasms throughout the liver in the control group. There were no differences in the percentage of metastases between the anterior and posterior lobes in the control group (36% ± 3% vs 29% ± 4%; P = .451) (Fig 1). The absolute number of metastases in the left posterior liver lobe in controls was
Discussion
Cancer recurrence after operative resection of colorectal liver metastases is remarkably high despite preoperative staging using several techniques to identify all metastatic disease.1, 4, 15 The liver is the predominant site of recurrent disease in approximately 50% of patients.1, 4, 15 More recently, thermal ablation by radiofrequency and laser ablation have been used for the treatment of liver neoplasms, with data suggesting similar survival rates to operative resection in selected patients.1
References (38)
- et al.
Partial hepatectomy accelerates local tumor growth: potential roles of local cytokine activation
Surgery
(1998) - et al.
Preliminary report of tumor metastasis during liver regeneration after hepatic resection in rats
Eur J Surg Oncol
(1995) - et al.
The effect of partial hepatectomy on tumor growth in rats: in vivo and in vitro studies
Hepatology
(1995) - et al.
Scanning electron microscopy study of the blood supply of human colorectal liver metastases
Eur J Surg Oncol
(2003) - et al.
Focal hyperthermia produces progressive tumor necrosis independent of the initial thermal effects
J Gastrointest Surg
(2005) - et al.
Microwave coagulation therapy accelerates growth of cancer in rat liver
J Hepatol
(2002) Influence on metastatic spread of whole-body or local tumor hyperthermia
Eur J Cancer
(1976)Tumor angiogenesis
Adv Cancer Res
(1985)- et al.
Advances in the treatment of liver tumors
Curr Probl Surg
(2002) - et al.
Interstitial laser thermotherapy for liver tumours
Br J Surg
(2003)