Meta-analysisComparison of the effectiveness of radiotherapy with photons, protons and carbon-ions for non-small cell lung cancer: A meta-analysis
Section snippets
Methods
This meta-analysis was performed according to the guidelines proposed by the Meta-Analysis of Observational Studies in Epidemiology group [15].
Selected articles and characteristics
Regarding the search on CRT and SBRT, on the basis of the keywords, 1711 articles were found. Excluding papers with review as publication type left 1289, of which another 1102 were excluded based on the screening of the titles. Most excluded references were papers on chemoradiation, advanced stage NSCLC or planning studies. Of the remaining 187 references the abstracts were screened and, if necessary, the papers were retrieved and the data were analyzed. Of these 187 references another 159 were
Discussion
To the best of our knowledge, this meta-analysis was the first to pool the effectiveness of CRT, SBRT, proton therapy and carbon-ion therapy in the treatment of stage I NSCLC, to allow for a comparison between particle therapy and photon therapy. A total of 30 studies met the inclusion criteria and were used in the meta-analysis. Two- and five-year (disease-specific) survival rates, corrected for differences in the percentage of medically inoperable patients in the studies, were lower for CRT
Acknowledgement
This study was funded by an unrestricted grant from Siemens Medical Solutions.
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These authors contributed equally to this work.