Lung cancer SBRTA phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer
Section snippets
Patient eligibility
All patients included in this study had histological or cytological diagnoses of NSCLC and were staged as Union International Contre le Cancer (UICC) stage IA or IB (up to 5 cm) after appropriate staging studies. All the patients had either a medical contraindication to surgery or refused surgery. Further, all had a performance status of ⩽2 according to the World Health Organization guidelines. Patient eligibility was not restricted on the basis of tumour location, unless a part of the
Patients
Between March 1998 and December 2004, 34 patients with stage I NSCLS were registered with this study. However, 3 patients were excluded due to dose constraints related to the heart, hilus, and oesophagus, respectively. We treated 31 patients with stage I NSCLC with hypofractionated high-dose SBRT at Tohoku University Hospital (Table 1). Of the 31 patients, 20 were medically inoperable and 11 refused surgery. Further, 25 patients were men and 6 were women. Their median age was 77 years (range,
Discussion
The optimum protocol of SBRT for NSCLC has not been established, although several protocols and clinical results have been previously reported [16], [19], [32]. When we designed this protocol, 2 clinical results of SBRT had been reported for stage I NSCLC [1], [31]. Both reported excellent local control rates of >90% using 50 Gy/5 fractions [31] and 60 Gy/8 fractions [1]. We calculated biologic effective dose (BED) as nd [(1 + d/α/β), where n is the number of fractions, d is the fraction size, and α
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