Original articleSebaceous carcinoma of the eyelids: Personal experience with 60 cases
Section snippets
Patients and methods
This study was approved by the Institutional Review Board at Wills Eye Hospital of Thomas Jefferson University. A detailed retrospective chart review was conducted on all patients with sebaceous carcinoma who were evaluated on the Oncology Service from February 1974 through June 2003. Data tabulated included general and demographic information, initial clinical and histopathologic diagnoses elsewhere, initial treatment elsewhere, initial symptoms and signs, visual acuities, anatomic sites of
Results
There were 60 patients with sebaceous carcinoma of the eyelid or adjacent tissues who were evaluated and managed at the Oncology Service. The 4 patients cited in Rundle et al,16 Margo and Grossniklaus,17 Lisman et al,18 and Shields et al,19 respectively, had their cases discussed in unusual case reports, before our decision to report this larger statistical series. Pertinent general data are shown in Table 1. There were no related specific systemic diseases, except for one patient who had a
Discussion
There have been only a few sizable reports of sebaceous carcinoma of the ocular adnexa.4, 5, 6, 7, 8, 12, 13, 14 Most of these larger series were derived from eye pathology laboratories that had limited clinical information and received specimens from a variety of physicians. The series reported here represents, to our knowledge, the largest clinical experience with patients managed by one team reported in the English language literature.
In agreement with prior reports, we found that sebaceous
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Manuscript no. 240375.
Supported by the Eye Tumor Research Foundation, Philadelphia, Pennsylvania; Retina Research Foundation, Houston, Texas (Award of Merit in Retina Research) (JAS); and Macula Foundation, New York, New York (CLS).