Elsevier

Medical Hypotheses

Volume 82, Issue 3, March 2014, Pages 403-404
Medical Hypotheses

Correspondence
Mesogastrium recurrence as expression of the fifth metastatic route of gastric cancer

https://doi.org/10.1016/j.mehy.2014.01.005Get rights and content

References (2)

Cited by (15)

  • Clinicopathological factors associated with the presence of tumor deposits in resected gastric cancer patients

    2021, Heliyon
    Citation Excerpt :

    In 2009, in the 7th edition of the TNM classification for colorectal cancer, the presence of TDs without lymph node metastasis was classified as pathological node stage 1c (pN1c) [12]. Gastric cancer is the pathology with the second largest number of TDs studies only after colorectal cancer [13, 14, 15, 16]. By consensus, TDs are defined as tumoral nodules in perigastric adipose tissue within the primary tumor's drainage area without evidence of lymphatic, vascular, or neural tissue [3].

  • Long non-coding RNAs in the gastric juice of gastric cancer patients

    2018, Pathology Research and Practice
    Citation Excerpt :

    Accounting approximately for 80% of ncRNAs, lncRNAs represent another class of genomic transcripts which do not have protein encoding functions; however, serving as oncogenes or tumor suppressor genes, they are believed to promote or inhibit the initiation and progression of cancers [4,28]. Concerning GC, however, since the current knowledge on GC-specific lncRNAs -including their functions- is still scarce and most studies dealing with lncRNAs were conducted analyzing serum or tissue of affected patients, recently some authors started investigating such markers in another body fluid: the GJ [12–24,39–41]. Such a biological matter, in fact, shows some interesting aspects and potential advantages.

  • Preoperative gastric lavage in gastric cancer patients undergoing surgical, endoscopic or minimally invasive treatment: An oncological measure preventing peritoneal spillage of intragastric cancer cells and development of related metastases

    2018, Medical Hypotheses
    Citation Excerpt :

    Traditionally, GC is recognized to follow four main routes of metastasis: direct invasion (also known as Metastasis I), hematogenous pathway (Metastasis II), lymphatic metastasis (Metastasis III) and peritoneum dissemination (Metastasis IV) [4,5]. More recently, a new fifth pattern has been identified and designated by Xie and colleagues as Metastasis V (mesogastrium pathway) [5–7]. As explained by the authors, spread of metastatic GC cells within different cavities depends on different forces: Metastasis I and IV spread in the serous cavities adopting a free autonomous scattering or movement, Metastasis II spreads in blood vessels cavities driven by circulation of the blood stream, Metastasis III spreads in the lymphatic cavities headed by circulation of the lymphatic stream whereas Metastasis V spreads through fat tissues within the proper fascia cavity after down-regulating DAB2IP and E-cadhering expression as well as increasing β-catenin and p65 (DAB2IP-mediated Wnt pathway) [6].

  • Development of membrane anatomy theory in gastric cancer surgery

    2023, Chinese Journal of Gastrointestinal Surgery / Zhonghua Wei Chang Wai Ke Za Zhi
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