ReviewDown syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging
Highlights
► DNA base excision repair is reduced in individuals with Down syndrome. ► Loss of base excision repair may play a role in the aging phenotype of Down syndrome. ► Aberrant folate metabolism in Down syndrome may impact DNA repair capacity. ► Overexpression of chromosome 21 localized miRNAs may impact folate metabolism.
Section snippets
Acknowledgements
This work was supported by grants from the Ellison Medical Foundation (DCC), the American Federation for Aging Research (DCC), the Lowe Fund of the Denver Foundation (DP), and the Alvin Itkin Foundation (DP). The authors would also like to acknowledge Jeffrey W. Taub and his efforts in developing the folate-trap model of leukemogenesis in Down syndrome.
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