Review
Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging

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Abstract

Down syndrome is a condition of intellectual disability characterized by accelerated aging. As with other aging syndromes, evidence accumulated over the past several decades points to a DNA repair defect inherent in Down syndrome. This evidence has led us to suggest that Down syndrome results in reduced DNA base excision repair (BER) capacity, and that this contributes to the genomic instability and the aging phenotype of Down syndrome. We propose important roles for microRNA and/or folate metabolism and oxidative stress in the dysregulation of BER in Down syndrome. Further, we suggest these pathways are involved in the leukemogenesis of Down syndrome. We have reviewed the role of BER in the processing of oxidative stress, and the impact of folate depletion on BER capacity. Further, we have reviewed the role that loss of BER, specifically DNA polymerase beta, plays in accelerating the rate of aging. Like that seen in the DNA polymerase beta heterozygous mouse, the aging phenotype of Down syndrome is subtle, unlike the aging phenotypes seen in the classical progeroid syndromes and mouse models of aging. As such, Down syndrome may provide a model for elucidating some of the basic mechanisms of aging.

Highlights

DNA base excision repair is reduced in individuals with Down syndrome. ► Loss of base excision repair may play a role in the aging phenotype of Down syndrome. ► Aberrant folate metabolism in Down syndrome may impact DNA repair capacity. ► Overexpression of chromosome 21 localized miRNAs may impact folate metabolism.

Section snippets

Acknowledgements

This work was supported by grants from the Ellison Medical Foundation (DCC), the American Federation for Aging Research (DCC), the Lowe Fund of the Denver Foundation (DP), and the Alvin Itkin Foundation (DP). The authors would also like to acknowledge Jeffrey W. Taub and his efforts in developing the folate-trap model of leukemogenesis in Down syndrome.

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