Basic and patient-oriented researchPrognostic Factors in Intraoral Squamous Cell Carcinoma: The Influence of Histologic Grade
Section snippets
Materials and Methods
Data were retrospectively collected on all patients from the Cancer Data Registry at Legacy Emanuel Hospital (Portland, OR) who presented with a primary diagnosis of OCSCC over a 10-year period from January 1, 1993 to January 1, 2003. Data collected included demographic information, site, size, TNM stage at diagnosis, histologic grade, presence of neck disease at presentation, treatment, presence or absence of positive margins, recurrence, and whether adjuvant radiotherapy or chemoradiotherapy
Results
Two hundred forty-two records on 233 patients were collected and reviewed. Of these, 9 patients did not undergo their primary surgery at Legacy Emanuel Hospital and were excluded. Eight patients were excluded because of incomplete medical records, leaving 225, or 93% of the patient records, that meet criteria for inclusion into the study.
The two hundred twenty-five patients consisted of 119 males (48%) and 123 females (52%), with an average age at diagnosis of 66 years (SD ± 14). Average tumor
Discussion
OCSCC continues to have a poor overall prognosis with a strong tendency to recur both at the primary site and regionally in the cervical lymph nodes.2, 6 It is well known that OCSCC displays varying biologic behavior patterns, dependent on several host and primary tumor factors. In particular, grade was found to be a significant predictor of locoregional failure and tumor recurrence in our study population. The presence of lymph node metastasis as a marker of overall patient prognosis is
References (19)
- et al.
Carcinoma of the oral cavityFactors affecting treatment failure at the primary site and neck
Am J Surg
(1976) - et al.
Predictive value of tumor thickness in squamous cell carcinoma confined to the tongue and floor of the mouth
Am J Surg
(1986) - et al.
Significance of positive margins in oral cavity squamous cell carcinoma
Am J Surg
(1990) - et al.
Evaluation of the dose for postoperative radiation therapy of head and neck cancerFirst report of a randomized clinical trial
Int J Radiat Oncol Biol Phys
(1993) Orofacial neoplasmsGlobal epidemiology, risk factors and recommendations for research
Int Dent J
(1991)- et al.
The epidemiology of mouth cancer
Oral Dis
(2000) Cervical lymph node metastasis, its diagnostic, therapeutic and prognostic implications
Oncology
(1990)- et al.
Prognostic significance of lymphatic spread in head and neck carcinomastherapeutic implications
Head Neck Surg
(1985) - et al.
Recurrence at the primary site in head and neck cancer and the significance of neck lymph node metastasis as a prognostic factor
Cancer
(1994)
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