CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease

doi:10.1016/j.jhep.2012.08.018

Journal of Hepatology

Volume 58, Issue 2, February 2013, Pages 395-398

https://doi.org/10.1016/j.jhep.2012.08.018 Get rights and content

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Summary

Alcoholic (ALD) and non-alcoholic fatty liver diseases (NAFLD) are clinical conditions leading to hepatocellular injury and inflammation resulting from alcohol consumption, high fat diet, obesity and diabetes, among others. Oxidant stress is a major contributing factor to the pathogenesis of ALD and NAFLD. Multiple studies have shown that generation of reactive oxygen species (ROS) is key for the progression of fatty liver to steatohepatitis. Cytochrome P450 2E1 (CYP2E1) plays a critical role in ROS generation and CYP2E1 is also induced by alcohol itself. This review summarizes the role of CYP2E1 in ALD and NAFLD.

Abbreviations

hydroxyl radical

ADH

alcohol dehydrogenase

ALD

alcoholic liver disease

CYP2E1

cytochrome P450 2E1

endoplasmic reticulum

GSH

glutathione

H₂O₂

hydrogen peroxide

MEOS

microsomal ethanol-oxidizing system

NADPH

nicotinamide adenine dinucleotide phosphate

NAFLD

non-alcoholic fatty liver disease

NASH

non-alcoholic steatohepatitis

O₂⁻

superoxide radical

ROS

reactive oxygen species

Keywords

Cytochrome P450

Alcoholic liver disease

Non-alcoholic fatty liver disease

Journal of Hepatology

Clinical Application of Basic ScienceCYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease

Summary

Abbreviations

Keywords

Clinical Application of Basic Science
CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease