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Reports of Unexpected Late Side Effects of Accelerated Partial Breast Irradiation—Radiobiological Considerations

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  • Outcomes and toxicities after proton partial breast radiotherapy for early stage, hormone receptor positive breast cancer: 3-Year results of a phase II multi-center trial

    2022, Clinical and Translational Radiation Oncology
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    In the MGH and NCC experiences, daily dose delivered ranged from 6 to 8 Gy (4 Gy(RBE) BID). [27–29] Large fraction size and inadequate recovery time between fractions can increase risk of late effects [55], which, in combination with the number of fields treated per fraction, may worsen cosmesis. However, in the Mutter et al study, even with 9.3 Gy(RBE) fractions, favorable early outcomes was reported, possibly due to ample recovery between daily fractions and use of two-field plans. [33]

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