Original articleClinical endoscopyIncidence of esophageal adenocarcinoma in patients with Barrett's esophagus and high-grade dysplasia: a meta-analysis
Section snippets
Search criteria
Studies were systematically searched independently by 2 investigators in MEDLINE (1966 to January 2006), PubMed, Ovid journals, the Database of Abstracts of Reviews of Effect, ACP Journal Club, the Cumulative Index to Nursing and Allied Health Literature, International Pharmaceutical Abstracts, old MEDLINE, MEDLINE Nonindexed Citations, BIOSIS Previews, the Food and Drug Administration database, and Cochrane Control Trial Registry. The key words used to search were Barrett's esophagus, BE, high
Search findings
Our initial search yielded 3843 citations. Of these, 196 articles were relevant, and these were retrieved and reviewed. Finally, 4 of 196 articles were selected, because they met all the inclusion and exclusion criteria. The rest were excluded because they did not meet the inclusion criteria. There was complete agreement between the investigators on selection of these studies.
Study characteristics
Three of the studies were conducted in a single center,19, 20, 21 and 1 was a multicenter study by Overholt et al.22 The
Discussion
Despite the lack of high-level evidence for a survival advantage, endoscopic screening of patients with long-standing reflux and surveillance of patients with BE have been proposed.23, 24 With increasing numbers of screening upper endoscopies being performed, there has been a rise in the detection and recognition of BE as well as HGD.14 Circumstantial evidence indicates the sequential histologic alteration from BE with no dysplasia to low-grade dysplasia followed by HGD and finally
Acknowledgment
This study was supported by the Veterans' Affairs Medical Center, Kansas City, Missouri.
References (31)
- et al.
Barrett's esophagus. A prevalent, occult complication of gastroesophageal reflux disease
Gastroenterology
(1987) - et al.
Adenocarcinoma and Barrett's esophagus. An overrated risk?
Gastroenterology
(1984) - et al.
Prevalence and characteristics of Barrett esophagus in patients with adenocarcinoma of the esophagus or esophagogastric junction
Hum Pathol
(1988) - et al.
Barrett's metaplasia and adenocarcinoma of the esophagus and gastroesophageal junction
Hum Pathol
(1983) - et al.
Barrett's esophagus: cell cycle abnormalities in advancing stages of neoplastic progression
Gastroenterology
(1993) - et al.
Effects of operative volume on morbidity, mortality, and hospital use after esophagectomy for cancer
J Thorac Cardiovasc Surg
(2000) - et al.
Curative endoscopic resection of early esophageal adenocarcinomas (Barrett's cancer)
Gastrointest Endosc
(2007) - et al.
Meta-analysis in clinical trials
Control Clin Trials
(1986) - et al.
Long-term nonsurgical management of Barrett's esophagus with high-grade dysplasia
Gastroenterology
(2001) - et al.
Predictors of progression to cancer in Barrett's esophagus: baseline histology and flow cytometry identify low- and high-risk patient subsets
Am J Gastroenterol
(2000)
Long-term follow-up of Barrett's high-grade dysplasia
Am J Gastroenterol
Photodynamic therapy with porfimer sodium for ablation of high-grade dysplasia in Barrett's esophagus: international, partially blinded, randomized phase III trial
Gastrointest Endosc
Practice Parameters Committee of the American College of Gastroenterology. Updated guidelines for the diagnosis, surveillance, and therapy of Barrett's esophagus
Am J Gastroenterol
A critical review of the diagnosis and management of Barrett's esophagus: the AGA Chicago Workshop
Gastroenterology
High-grade dysplasia in Barrett's esophagus. The case for esophagectomy
Chest Surg Clinic
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