Original articleNoninvasive Versus Histologic Detection of Gastric Atrophy in a Hispanic Population in North America
Section snippets
Study Design
The study was done in Ciudad Juarez, Mexico, which is on the US-Mexico border contiguous to El Paso, Texas. This was a cross-sectional study in which volunteers were recruited from a random sample of households selected by means of a multistage cluster, self-weighted design. The survey was designed to be self-weighted and stratified by age and sex. In the first stage, census tracts were selected (ie, primary sampling unit) with probability proportional to their size. In the second, blocks were
Study Population Demographics and Prevalence of Helicobacter pylori Infection
A total of 180 adult volunteers ranging in age from 17–82 years participated, 76 men and 104 women. The overall seropositivity rate of H pylori infection as defined above was 76%, increasing from 55.2% in the age 17–29 group to 90.3% at ages 50–59. There was no significant difference in the overall prevalence of H pylori infection between men and women (78.4% vs 74.5%).
Prevalence of Gastric Atrophy
Adequate biopsy specimens to assess corpus atrophy were available from 178 subjects, and data for antral atrophy were available
Discussion
It is now generally accepted that epidemic noncardiac gastric cancer is etiologically associated with H pylori infection, and that the presence of atrophic gastritis is the primary easily identifiable risk factor.1 Changes in environmental factors including diet, food storage, and sanitation have resulted in a major reduction in the prevalence of H pylori and of gastric cancer among those with the infection.26 Eradication of H pylori at a nonatrophic stage will likely prevent the subsequent
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2021, Digestive and Liver DiseaseCitation Excerpt :In Kimura's classification, this feature is reflected by atrophic patterns (of increasing severity) endoscopically distinguishable from the location of the atrophic border (closed types C-0 to C-3; open types O-1 to O-3, and pangastritis (O-p) [33,43,44,68,69]. PPM and IM are both consistent with the histolological definition of mucosal atrophy, and both give rise to a “serological atrophic profile” due to the organic loss of oxyntic glandular units, with a drop in serum PgI levels and the PgI/PgII ratio [70–75]. Other, minor variants of metaplastic transformation of gastric epithelial cells (e.g. ciliated, or pseudo-pancreatic metaplasia) are clinically and biologically irrelevant [11].
Prevalence of Helicobacter pylori infection in Latin America and the Caribbean populations: A systematic review and meta-analysis
2019, Cancer EpidemiologyCitation Excerpt :A total of 2018 manuscripts were identified in the period; of these, 525 were duplicated and therefore excluded from the study. After reading the titles and abstracts, 251 papers were selected for full reading; of these, 22 studies [13–34] fulfilled the eligibility criteria and were included (Fig. 1). The 22 selected studies were carried out in 14 countries of LAC, and included 24,178 individuals.
Long-term follow-up of pepsinogen I/II ratio after eradication of Helicobacter pylori in patients who underwent endoscopic mucosal resection for gastric cancer
2017, Digestive and Liver DiseaseCitation Excerpt :Hence, the ratio of PGI/II decreases. The PGI/II ratio has been proposed as a non-invasive marker for the prediction of gastric precancerous lesions [8,9]. In Japan, SPG tests have been proposed as the first step in GC screening, instead of photofluorography [10].
Fundic gland polyps accurately predict a low risk of future gastric carcinogenesis
2014, Clinics and Research in Hepatology and GastroenterologyCitation Excerpt :It is one limitation of our study. However, several research groups in Western countries suggested efficacy of pepsinogen and H. pylori antibody to differentiate subjects with and without atrophic gastritis [30–33]. Moreover, a recent report from Portugal showed good adherence of Western individuals to the pepsinogen test in the detection of gastric cancer [12].
Update on Serum Biomarkers in Autoimmune Atrophic Gastritis
2023, Clinical Chemistry
Supported in part by the Office of Research and Development, Medical Research Service, Department of Veterans Affairs, by Public Health Service grant DK56338 which funds the Texas Gulf Coast Digestive Diseases Center, and by a grant from Biohit Diagnostics, Helsinki, Finland. No for-profit company had any input into the study design or analyses. Dr Graham receives royalties from Baylor College of Medicine from a patent on the antigen used in the HM-CAP serologic test. The Mexican Institute for Social Security authorized the use of the General Hospital Region 6 endoscopic facility and staff support to conduct the endoscopies.