Cancer Cell
Volume 22, Issue 3, 11 September 2012, Pages 373-388
ArticleSuppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells
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Highlights
► Docetaxel-resistant cells are undifferentiated and overexpress developmental pathways ► Docetaxel-resistant cells associate with poor clinical outcome in prostate cancer ► Notch and Hedgehog signaling inhibition depletes Docetaxel-resistant cells ► Docetaxel-resistant cells have high tumor-initiating capacity
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Present address: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
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Present address: Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
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