Facile synthesis of SSR180575 and discovery of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[18F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, a potent pyridazinoindole ligand for PET imaging of TSPO in cancer
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Acknowledgment
We acknowledge funding from the National Institutes of Health (K25 CA127349, P50 CA128323, S10 RR17858, U24 CA126588, 1R01 CA163806, P50 CA095103, P30 DK058404), The Kleberg Foundation, and The Lustgarten Foundation. Dr. M. Noor Tantawy, George H. Wilson, and Dr. Daniel Colvin are acknowledged for support of the imaging studies.
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