Short CommunicationSelective increase in the association of the β2 adrenergic receptor, β Arrestin-1 and p53 with Mdm2 in the ventral hippocampus one month after underwater trauma☆
Highlights
► Underwater trauma (UWT) causes heightened anxiety one month after trauma. ► UWT increases association of Mdm2 with beta2AR, beat Arrestin-1, and p53 in ventral not dorsal CA1. ► Stress-related events cause changes in ‘emotion-related’ parts of the hippocampus.
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Cited by (19)
Exploring the involvement of Tac2 in the mouse hippocampal stress response through gene networking
2019, GeneCitation Excerpt :We identified seven genes (Arrb1, Ndn, Dom3z, Rangap1, Spock1, Magel2, Mylk2) with non-synonymous SNPs in our network. One gene of interest is Arrb1 (Arrestin Beta 1), whose protein product has been previously identified as a mediator of DNA damage various brain structures in response to acute stress (Sood et al., 2013), chronic stress (Hara et al., 2011; Hara et al., 2013) and stress-related catecholamines (Jia et al., 2014). Theoretical effects of Arrb1 expression have been proposed to play a role in both general development of neuropsychiatric conditions and plastic changes in the hippocampal ventral CA1 region relating to its connectivity to the amygdala and hypothalamus (so called ‘emotion-related’ connections) (Hara et al., 2011; Hara et al., 2013; Sood et al., 2013).
Distinct Proteomic, Transcriptomic, and Epigenetic Stress Responses in Dorsal and Ventral Hippocampus
2018, Biological PsychiatryCitation Excerpt :Furthermore, dHC and vHC show opposite electrophysiological responses to the stress hormone corticosterone (17). One month after an acute traumatic stress experience, rats were found to be more anxious and showed increased beta-adrenergic receptor-2 binding to downstream effector proteins in the vHC but not in the dHC (60), and the immediate early gene Fos was primed for activation in the vHC (47). In addition, stress induces different epigenetic changes in dHC and vHC.
Juvenile adversity and adult threat controllability in translational models of stress-related disorders
2017, Current Opinion in Behavioral SciencesCitation Excerpt :In parallel to its long-term augmentation of anxious-like behavior [44,45], this procedure induces acute and enduring alterations in cortico-limbic circuits. Recent studies demonstrated that the mere exposure to the UWT induces critical alterations in hippocampal functions, evident after 24 hours [46] and up to 4 weeks [44,45] after exposure. Furthermore, the UWT can be easily paired with contextual stimuli and thus enables to model the cued re-experiencing of the trauma, a core symptom of PTSD, in fear-conditioned rodents [33,46,47].
Behavioral profiling as a translational approach in an animal model of posttraumatic stress disorder
2016, Neurobiology of DiseaseCitation Excerpt :In the current study, we used brief restraint under water (underwater trauma), as the traumatic stressor. This procedure is known to acutely and enduringly increase anxiety-like behavior (Ardi et al., 2014; Richter-Levin, 1998; Sood et al. 2013) without any tissue damage (Moore et al., 2012). We could confirm these results by analyzing activity and anxiety-like behaviors in the EPM and OF four weeks later on the group level, thus further supporting the relevance of UWT as an animal model of trauma-related PTSD.
Underwater trauma causes a long-term specific increase in the expression of cyclooxygenase-2 in the ventral CA<inf>1</inf> of the hippocampus
2014, PsychoneuroendocrinologyCitation Excerpt :This is supported by a recent study where exposure of animals to high level stressors such as forced swim or to the stress hormone corticosterone, caused a marked reduction of long-term potentiation (LTP) in dorsal CA1 and a parallel increase in the ventral CA1 (Maggio and Segal, 2009). These results are also in accordance with our recent work that showed a significant increase in the association of Mdm2 with the β2-adrenergic receptor, β-Arrestin-1, and p53 in the ventral but not dorsal CA1 of animals that underwent underwater trauma (Sood et al., 2013). We have also recently shown that re-exposure of animals to underwater trauma 24 h following the first event caused a significant increase in activation of the ERK MAP kinase pathway in the ventral hippocampus and the basolateral amygdala, suggesting a specific pattern of neural activation during recollection of a trauma reminder (Ritov et al., 2014).
The effects of a reminder of underwater trauma on behaviour and memory-related mechanisms in the rat dentate gyrus
2014, International Journal of Neuropsychopharmacology
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Research support: The Israel Science Foundation grant (no. 1403/07) to G.R.-L., by a U.S. Army Medical Research Acquisition Activity (USAMRAA) grant (no. W81XWH-11-20111), and by the Institute for the Study of Affective Neuroscience, University of Haifa, which was endowed by the Hope for Depression Research Foundation.
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