Review
Inhibitors of sphingolipid metabolism enzymes

https://doi.org/10.1016/j.bbamem.2006.08.017Get rights and content
Under an Elsevier user license
open archive

Abstract

Sphingolipids are a family of lipids that play essential roles both as structural cell membrane components and in cell signalling. The cellular contents of the various sphingolipid species are controlled by enzymes involved in their metabolic pathways. In this context, the discovery of small chemical entities able to modify these enzyme activities in a potent and selective way should offer new pharmacological tools and therapeutic agents.

Abbreviations

CBA
Conduritol B aziridine
CBE
Conduritol B epoxide
CDases
Ceramidases
Cer
Ceramide(s)
CerK
Ceramide kinase
CerP
Ceramide-1-phosphate
CerS
Ceramide synthase
DAG
Diacylglycerol
DES
Dihydroceramide desaturase
DHS
d,l-threo-Dihydrosphingosine
DMS
N,N-Dimethylsphingosine
DNJ
Deoxynojirimycin
ER
Endoplasmic reticulum
ERT
Enzyme replacement therapy
FB1
Fumonisin B1
GlcCer
Glucosylceramide
GlcCerase
Glucocerebrosidase
GlcCerS
Glucosylceramide synthase
GSH
Glutathione
GSLs
Glycosphingolipids
LacCer
Lactosylceramide
LacCerS
Lactosylceramide synthase
NBDGJ
N-Butyldeoxygalactonojirimycin
NBDNJ
N-Butyldeoxynojirimycin
NNDNJ
N-Nonyldeoxynojirimycin
NOE
N-Oleoylethanolamine
NOV
N-Octylvalienamine
PKC
Phosphokinase C
SAP
Sphingolipid-activator protein
SLs
Sphingolipids
SM
Sphingomyelin
SMase
Sphingomyelinase
SMS
Sphingomyelin synthase
Sph
Sphingosine
SphK
Sphingosine kinase
SphP
Sphingosine-1-phosphate
SphPL
Sphingosine-1-phosphate lyase
SPT
Serine palmitoyltransferase
SRT
Substrate reduction therapy

Keywords

Biosynthesis
Sphingolipids
Metabolism
Inhibitor
Enzyme

Cited by (0)