Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1864, Issue 12, December 2018, Pages 3786-3798
YM155 sensitizes non-small cell lung cancer cells to EGFR-tyrosine kinase inhibitors through the mechanism of autophagy induction
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Abbreviations
EGFR
epidermal growth factor receptor
TKIs
tyrosine kinase inhibitors
NSCLC
non-small cell lung cancer
PTEN
phosphatase and tensin homolog deleted on chromosome ten
CQ
chloroquine
3MA
3-methyladenine
PARP
poly (ADP-ribose) polymerase
LC3
microtubule-associated protein 1 light chain 3
ATG
autophagy-related gene
Beclin1
Bcl-2-interacting protein1
siRNA
small interfering RNA
SQSTM1
sequestosome 1
mTOR
mammalian target of rapamycin
AKT
protein kinase B
ERK
extracellular signal-regulated kinase
JNK
c-jun N-terminal kinase
ATM
ataxia telangiectasia mutated
DDR
DNA repair response
DSB
double strand breaks
Keywords
Non-small cell lung cancer
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs)
Erlotinib
Resistance
YM155
Survivin
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These authors contributed equally to this work.
© 2018 Elsevier B.V.