Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1822, Issue 6, June 2012, Pages 843-851
TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis
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Highlights
► CDX2 regulates MEP1A expression in intestinal epithelial cells. ► CDX2 and MEP1A expression are correlatively decreased in intestinal inflammation. ► High levels of TNF-α suppresses the ability of CDX2 to activate MEP1A expression. ► A dysfunction of CDX2 is a key contributor in the pathogenesis of IBD.
Abbreviations
CD
Crohn's disease
CDX2
Caudal-related homeobox transcription factor 2
ChIP
chromatin immunoprecipitation
CK20
cytokeratin 20
CLDN2
claudin-2
DAI
disease activity index
DSS
dextran sodium sulfate
GAPDH
glyceraldehyde 3-phosphate dehydrogenase
GSK3β
glycogen synthase kinase-3β
HA
hemagglutinin
HNF4α
hepatocyte nuclear factor 4 alpha
IBD
inflammatory bowel disease
IEC
intestinal epithelial cell
IFX
infliximab
IHC
immunohistochemistry
INF-γ
interferon-γ
MEP1A
meprin 1A
MUC2
mucin 2
NF
nuclear factor
PEPT1
peptide transporter 1
qRT-PCR
quantitative reverse-transcription polymerase chain reaction
RPLP0
ribosomal protein large p0
TNF-α
tumor necrosis factor-α
UC
ulcerative colitis
Keywords
DSS-colitis
Inflammatory bowel disease
Infliximab
Intestine
Tumor necrosis factor
Ulcerative colitis
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