Original articleGeneral thoracicLong-Term Outcomes After Surgical Resection of Pulmonary Metastases From Colorectal Cancer
Section snippets
Patients and Methods
Between November 1991 and April 2013, 136 surgical resections were performed at Ibaraki Prefectural Central Hospital in 102 patients for pulmonary metastases from colorectal cancer. The study excluded patients with a history of pulmonary metastasectomy at other hospitals or with incomplete resection. The medical records of the remaining 94 patients who underwent complete resection of pulmonary metastases were reviewed.
Our criteria for resection of pulmonary metastases included unilateral or
Patient Characteristics
Included were 60 men and 34 women, and the median age at pulmonary resection was 66 years (range, 43 to 82 years). The primary cancer was located in the colon in 41 patients and in the rectum in 53. Synchronous metastases with primary tumor, or stage IV colorectal cancer, were initially present in 30 patients (liver in 16 patients, lungs in 12, and both in 2). Forty patients had a short disease-free interval (<1 year) before the detection of pulmonary metastases, and 54 patients had long
Comment
In this study we retrospectively investigated survival of 94 colorectal cancer patients who underwent complete resection of pulmonary metastases, and multivariate analysis indicated the preoperative CEA level was an independent prognostic factor. Despite the high incident rate of recurrence after pulmonary metastasectomy, surgical resection of the recurrent lesions in the liver or lungs, or both, provided longer survival.
The criteria for resection of pulmonary metastases were first described by
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2021, Critical Reviews in Oncology/HematologyCitation Excerpt :The results of quality assessment of prospective studies were presented as a risk of bias graph and a risk of bias summary figure in Supplement 5. A total of 60 studies reported OS and HR with 95 % Cl data according to clinicopathological or biological parameters (Schweiger et al., 2016; Menna et al., 2018; Hachimaru et al., 2016; Bhullar et al., 2019; Corsini et al., 2019; Renaud et al., 2015a; Ghidini et al., 2016; Passot et al., 2018; Nelson et al., 2019b; Renaud et al., 2019a, b; Davini et al., 2020; Mammana et al., 2021; Shimizu et al., 2019; Jarabo et al., 2018; Rapicetta et al., 2019; Imanishi et al., 2019; Sponholz et al., 2018; Al-Ameri et al., 2018; Renaud et al., 2017; Okumura et al., 2017; Ihn et al., 2017; Murakawa et al., 2017; Fournel et al., 2009; Ampollini et al., 2017; Dudek et al., 2017; Shiono et al., 2018; Park et al., 2017; Pagès et al., 2016; Hernández et al., 2016; Guerrera et al., 2016; Embun et al., 2016; Kobayashi et al., 2016; Kim et al., 2016b; Cho et al., 2015; Suzuki et al., 2015; Nozawa et al., 2015; Renaud et al., 2015b; Yaeger et al., 2014; Salah et al., 2013; Hirosawa et al., 2013; Blackmon et al., 2012; Hwang et al., 2010; Zabaleta et al., 2011; Borasio et al., 2011; Koga et al., 2006). Twenty parameters, with the most consistency and availability, were collected to analyze their prognostic value on outcome after PM for CRC, including age, sex, Eastern Cooperative Oncology Group performance status (ECOG PS), Charlson Comorbidity Index (CCI), CEA, DFI, distribution of LM, extrapulmonary metastases, number and size of LM, T and N stage, lymph nodes invasion, KRAS and v-raf murine sarcoma b-viral oncogene homolog B1 (BRAF) mutations, type of surgery and resection, and adjuvant chemotherapy, location of CRC, total stage.
Pulmonary metastasectomy for colorectal cancer: Prognosis analysis disaggregated by the origin of the primary tumor
2020, Asian Journal of SurgeryCitation Excerpt :Over the past decades, several studies have sought to identify patients with metastatic colorectal cancer who may benefit from PM. Previous reports on PM for metastatic CRC also indicated several favorable prognostic factors, such as single pulmonary metastasis, normal CEA level, no mediastinal lymph node involvement, unilateral distribution, or no liver metastasis.2,3,6–12 However, most of these studies regarded colorectal cancer as a single tumor entity.
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2020, International Journal of Surgery Case ReportsCitation Excerpt :In contrast, the role of surgical resection for pulmonary metastasis from gastric cancer remains unclear. The use of pulmonary metastasectomy has been proposed for solid tumors, such as sarcomas, adrenal cortical carcinomas and gastrointestinal cancers [7–9]. Although pulmonary resection for metastatic colorectal cancer is commonly performed in clinical practice, this is only based on retrospective studies; no randomized controlled trials have focused on the topic [9,10].
Cancer of the Rectum
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