2-Methoxyestradiol Exhibits a Biphasic Effect on VEGF-A in Tumor Cells and Upregulation Is Mediated Through ER-α: A Possible Signaling Pathway Associated with the Impact of 2-ME2 on Proliferative Cells1
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Keywords
2-methoxyestadiol
VEGF
ER-alpha
human mammary epithelial cells
transfection
Abbreviations
2-ME2
2-methoxyestradiol
BCEC
bovine capillary endothelial cell
CSPD
disodium 3-(4-methoxyspiro[1,2-dioxetane-3,2-(5-chloro)tricyclo[3.3.1.1,7]decan]-4-yl)phenyl phosphate
DIG
digoxigenin
ER
estrogen receptor
GAPDH
glyceraldehyde-3-phosphatedehydrogenase
HMEC
human mammary epithelial cell
MOPS
3-(N-morpholino)propanesulfonic acid
1 × PBS
1 × phosphate-buffered saline
PMSF
phenylmethylsulfonyl fluoride
VEGF-A
vascular endothelial growth factor-A
huMAb-VEGF-A
humanized monoclonal antibody directed against VEGF-A
Cited by (0)
- 1
This work is supported by NIH/NCI CA87680, V.A. merit review grant, the Midwest Biomedical Research Foundation grant, the EntreMed, Inc. research grant, the University of Kansas Medical Center departmental research grant.
- 2
Both authors have equal contributions to this work.
- 3
Present address: Zoology Department, Rammohan College, Kolkata, India.
Copyright © 2003 Neoplasia Press, Inc. Published by Elsevier Inc.