CommentVEGF Trap for the treatment of malignant ascites
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2014, Journal of HepatologyCitation Excerpt :Mechanisms by which VEGF inhibition may be beneficial include attenuation of mesenteric angiogenesis and portosystemic collaterals as well as reduction in intrahepatic vascular remodelling and fibrogenesis. Additional effects of VEGF inhibition on reduction in vascular permeability and ascites are also documented [103]. However, further studies are needed in humans and this is being pursued in an indirect manner through analysis of small molecule inhibitors of receptor tyrosine kinases such as sorafenib (with the understanding that these inhibitors target a multitude of receptor tyrosine kinases on different cell types) [10,104].
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