Elsevier

Microbes and Infection

Volume 3, Issue 2, February 2001, Pages 149-159
Microbes and Infection

The function of scavenger receptorsexpressed by macrophages and their rolein the regulation of inflammation

https://doi.org/10.1016/S1286-4579(00)01362-9Get rights and content
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Abstract

Macrophages are able to recognise and internalise apoptotic and foreign cells from the tissue microenvironment and, where pertinent, initiate inflammation and macrophage activation. Regulation of this protective response is important so as to prevent inappropriate activation of host cells and excessive tissue damage. Scavenger receptors (SRs) are widely expressed by macrophages and are able to bind a diverse array of endogenous and foreign molecules. Studies have concentrated on the role of the receptors in atherosclerosis as they can endocytose modified lipoproteins, however, this review will detail the accumulating evidence that SRs function in innate immunity and macrophage control during inflammation.

Keywords

scavenger receptor
LPS
inflammation

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