Brief review
Cell Biology of Tissue Factor, an Unusual Member of the Cytokine Receptor Family

https://doi.org/10.1016/S1050-1738(01)00137-2Get rights and content

Abstract

Tissue factor (TF) is a 47-kDa transmembrane protein, involved in the onset of coagulation. However, it also influences pathophysiological processes such as inflammation and tumor angiogenesis. Although the molecular mechanisms responsible for these phenomena remain unclear, it is thought that they are brought about by the action of intracellular signaling, resulting in gene transcription and subsequent protein synthesis. In this review we focus on FVIIa/TF-induced intracellular signaling and its possible role in physiology.

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Acknowledgements

The authors are grateful to Dr Tita Ritsema for her critical reading of this manuscript. The authors are supported by the “Nederlandse Hart Stichting” (NHS99.188).

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      Previous studies reported that cells lacking FLN have impaired locomotion [11,12]. TF, a member of the cytokine receptor family, is a 47‐kDa glycosylated transmembrane protein [13,14] whose activity is modulated by a variety of factors, including its membrane domain association, the phosphatidylserine transmigration to the outer leaflet of the plasma membrane [15,16] and the sphingomyelin levels [10]. TF activity is also modulated by the redox state of its membrane proximal cysteine pair (Cys186/Cys209) [17], as oxidation of this cysteine pair increases the procoagulant activity of TF.

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