The Journal of Steroid Biochemistry and Molecular Biology
Aromatase in the normal breast and breast cancer*
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Cited by (93)
The effect of environmental Bisphenol A exposure on breast cancer associated with obesity
2021, Environmental Toxicology and PharmacologyCitation Excerpt :Aromatase expression is measured in the cytoplasm of tumour epithelial cells and the surrounding stromal cells in more than half of the breast tumours. These data confirm that some breast cancers synthesize adequate estrogen to stimulate their own proliferation (Brodie et al., 1997). Additionally, environmental BPA exposure firmly induces up-regulation of aromatase mRNA and increases aromatase activity.
Expanding the view of breast cancer metabolism: Promising molecular targets and therapeutic opportunities
2016, Pharmacology and TherapeuticsCitation Excerpt :High levels of aromatase expression, measured using quantitative PCR, correlated with poor clinical outcomes (≈ 20 months shorter mean survival period) (Salhab et al., 2006), although this has not been observed in all studies (Lipton et al., 1992; Yoshimura & Kotake, 2004) (Zhang et al., 2003). Studies have also shown a positive correlation between aromatase expression and ER positive status (Brodie et al., 1997; Salhab et al., 2006). There is evidence that aromatase is present in a variety of cell types in breast tissue, including stromal and epithelial breast cancer cells (Santen et al., 1994; Shenton et al., 1998; Pauley et al., 2000; Miki et al., 2007), and macrophages (Leek et al., 1996; Mor et al., 1998).
Proteomic signatures of acquired letrozole resistance in breast cancer: Suppressed estrogen signaling and increased cell motility and invasiveness
2013, Molecular and Cellular ProteomicsCitation Excerpt :RT-PCR analysis was first performed on a panel of 88 genes involved in estrogen signaling and breast cancer survival to identify the most significantly altered genes as a result of acquired letrozole resistance. A total of 39 genes were up-(19) or down- (10) regulated by over threefold while several of which exhibited extremely large fold changes (Additional file 1, Table S1). It is evident that the ER regulated signaling was significantly suppressed, as key ER related gene expressions were dramatically decreased.
Retinol inhibits aromatase activity and expression in vitro
2011, Journal of Nutritional BiochemistryCitation Excerpt :It belongs to the cytochrome P450 family and is encoded by the CYP19 gene. The expression of aromatase is particularly high in breast tumor tissue and in the surrounding stroma in postmenopausal breast cancer patients [18,19]. Such intratumoral aromatase provides a source of local estrogen production that triggers estrogen-dependent cancer cell proliferation [20–22].
Aromatase and regulating the estrogen: Androgen ratio in the prostate gland
2010, Journal of Steroid Biochemistry and Molecular BiologyGenetic, Genomic, and Heritable Components of Benign Prostatic Hyperplasia
2023, Current Bladder Dysfunction Reports
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Proceedings of the IV International Aromatase Conference, Tahoe City, CA, U.S.A., 7–11 June 1996.